PDB: 2435 件ウェブページステータス検索Chemie searchBIRD

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6M8S	Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits 分子名称: BTB/POZ domain-containing protein KCTD12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 著者 Zheng, S, Kruse, A.C. 登録日 2018-08-22 公開日 2019-02-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.71 Å) 主引用文献 Structural basis for KCTD-mediated rapid desensitization of GABABsignalling. Nature, 567, 2019
6LO2	Crystal structure of EED in complex with EZH2 peptide and compound 11# 分子名称: 8-[4-[(dimethylamino)methyl]phenyl]-N-[(2-methoxyphenyl)methyl]-[1,2,4]triazolo[4,3-a]pyridin-5-amine, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED 著者 Zhao, K, Zhao, M, Luo, X, Zhang, H, Chen, Z. 登録日 2020-01-02 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Structure of EED in complex with EZH2 peptide and cmpd20 To Be Published
6LK8	Structure of Xenopus laevis Cytoplasmic Ring subunit. 分子名称: GATOR complex protein SEC13, MGC154553 protein, MGC83295 protein, ... 著者 Shi, Y, Huang, G, Yan, C, Zhang, Y. 登録日 2019-12-18 公開日 2021-07-21 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (5.5 Å) 主引用文献 Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis. Cell Res., 30, 2020
6N8S	Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). aPKC phosphorylated, crystal form 3. 分子名称: Lethal(2) giant larvae protein homolog 2 著者 Almagor, L, Weis, W.I. 登録日 2018-11-30 公開日 2019-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2. Proc.Natl.Acad.Sci.USA, 116, 2019
6N9G	Crystal Structure of RGS7-Gbeta5 dimer 分子名称: Guanine nucleotide-binding protein subunit beta-5, Regulator of G-protein signaling 7 著者 Patil, D.N, Rangarajan, E, Izard, T, Martemyanov, K.A. 登録日 2018-12-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.129 Å) 主引用文献 Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex. Elife, 7, 2018
6MZC	Human TFIID BC core 分子名称: Transcription initiation factor TFIID subunit 10, Transcription initiation factor TFIID subunit 12, Transcription initiation factor TFIID subunit 2, ... 著者 Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E. 登録日 2018-11-05 公開日 2018-11-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Science, 362, 2018
6N8R	Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). aPKC phosphorylated, crystal form 2. 分子名称: CHLORIDE ION, GLYCEROL, Lethal(2) giant larvae protein homolog 2 著者 Almagor, L, Weis, W.I. 登録日 2018-11-30 公開日 2019-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2. Proc.Natl.Acad.Sci.USA, 116, 2019
5VTB	Crystal structure of RBBP4 bound to BCL11a peptide 分子名称: B-cell lymphoma/leukemia 11A, GLYCEROL, Histone-binding protein RBBP4 著者 Meagher, J.L, Stuckey, J.A. 登録日 2017-05-16 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes. J. Biol. Chem., 293, 2018
6NQ3	Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex 分子名称: Histone-binding protein RBBP4, PHD finger protein 19, Polycomb protein SUZ12, ... 著者 Chen, S, Jiao, L, Liu, X. 登録日 2019-01-19 公開日 2020-01-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin. Mol.Cell, 77, 2020
5VK3	Apo ctPRC2 with E840A and K852D mutations in Ezh2 分子名称: Histone-lysine N-methyltransferase EZH2,Polycomb protein SUZ12, Polycomb Protein EED, ZINC ION 著者 Bratkowski, M.A, Liu, X. 登録日 2017-04-20 公開日 2017-06-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.114 Å) 主引用文献 Polycomb repressive complex 2 in an autoinhibited state. J. Biol. Chem., 292, 2017
5V4B	Crystal structure of the Skp1-FBXW7-DISC1 complex 分子名称: DISC1 peptide, F-box/WD repeat-containing protein 7, IMIDAZOLE, ... 著者 Li, Y, Baillie, G.S, Hao, B. 登録日 2017-03-08 公開日 2017-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Mol. Psychiatry, 23, 2018
6N8P	Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). Unphosphorylated, crystal form 1. 分子名称: CHLORIDE ION, Lethal(2) giant larvae protein homolog 2 著者 Almagor, L, Weis, W.I. 登録日 2018-11-30 公開日 2019-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.193 Å) 主引用文献 Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2. Proc.Natl.Acad.Sci.USA, 116, 2019
5VH9	Cryo-EM structure of yeast cytoplasmic dynein-1 with Lis1 and ATP 分子名称: Dynein heavy chain, cytoplasmic, Nuclear distribution protein PAC1 著者 Cianfrocco, M.A, DeSantis, M.E, Htet, Z.M, Tran, P.T, Reck-Peterson, S.L, Leschziner, A.E. 登録日 2017-04-12 公開日 2017-09-06 最終更新日 2020-01-01 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell, 170, 2017
5WAK	Crystal Structure of a Suz12-Rbbp4 Binary Complex 分子名称: Histone-binding protein RBBP4, Polycomb protein SUZ12, ZINC ION 著者 Chen, S, Jiao, L, Liu, X. 登録日 2017-06-26 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
5WBL	Crystal structure of the Arabidopsis thaliana Raptor in complex with the TOS peptide of human PRAS40 分子名称: Proline-rich AKT1 substrate 1, Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBK	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human S6K1 分子名称: Regulatory-associated protein of TOR 1, Ribosomal protein S6 kinase beta-1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
6M90	Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex 分子名称: 2-(2-fluorophenoxy)-3-{[2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid, Catenin beta-1, F-box/WD repeat-containing protein 1A, ... 著者 Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J. 登録日 2018-08-22 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
5WUK	Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound 分子名称: GLYCEROL, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... 著者 Chen, Z. 登録日 2016-12-19 公開日 2017-05-03 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Split luciferase-based biosensors for characterizing EED binders Anal. Biochem., 522, 2017
6N8Q	Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). Unphosphorylated, crystal form 2. 分子名称: CHLORIDE ION, GLYCEROL, Lethal(2) giant larvae protein homolog 2 著者 Almagor, L, Weis, W.I. 登録日 2018-11-30 公開日 2019-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2. Proc.Natl.Acad.Sci.USA, 116, 2019
5U62	Crystal structure of EED in complex with H3K27Me3 peptide and 6-(benzo[d][1,3]dioxol-4-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine 分子名称: (6S)-6-[(2H-1,3-benzodioxol-4-yl)methyl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine, GLYCEROL, Histone-lysine N-methyltransferase EZH2, ... 著者 Bussiere, D, Shu, W. 登録日 2016-12-07 公開日 2017-01-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem., 60, 2017
5U5T	Crystal structure of EED in complex with H3K27Me3 peptide and 3-(benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide 分子名称: (3R)-3-[(2H-1,3-benzodioxol-4-yl)methyl]piperidine-1-carboximidamide, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... 著者 Bussiere, D, Shu, W. 登録日 2016-12-07 公開日 2017-01-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem., 60, 2017
5WFC	Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK343 分子名称: Histone H3.1, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ... 著者 Bratkowski, M.A, Liu, X. 登録日 2017-07-11 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.282 Å) 主引用文献 An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
5WJC	Crystal structure of Schizosaccharomyces pombe Mis16 in complex with Eic1 分子名称: Eic1 protein, Kinetochore protein Mis16 著者 An, S, Cho, U.-S, Koldewey, P, Chik, J, Subramanian, L. 登録日 2017-07-21 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.298 Å) 主引用文献 Mis16 Switches Function from a Histone H4 Chaperone to a CENP-ACnp1-Specific Assembly Factor through Eic1 Interaction. Structure, 26, 2018
5VLJ	Cryo-EM structure of yeast cytoplasmic dynein with Walker B mutation at AAA3 in presence of ATP-VO4 分子名称: Dynein heavy chain, cytoplasmic, Nuclear distribution protein PAC1 著者 Cianfrocco, M.A, DeSantis, M.E, Htet, Z.M, Tran, P.T, Reck-Peterson, S.L, Leschziner, A.E. 登録日 2017-04-25 公開日 2017-09-06 最終更新日 2020-01-01 実験手法 ELECTRON MICROSCOPY (10.5 Å) 主引用文献 Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell, 170, 2017
5WAI	Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex 分子名称: Histone-binding protein RBBP4, Jumonji, AT-rich interactive domain 2, ... 著者 Chen, S, Jiao, L, Liu, X. 登録日 2017-06-26 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018

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