5M5G

Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)

Summary for 5M5G

Entry DOI	10.2210/pdb5m5g/pdb
Descriptor	putative polycomb protein EED, Putative uncharacterized protein, HISTONE H3 11-Mer peptide, ... (7 entities in total)
Functional Keywords	transferase, repressive, complex
Biological source	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) More
Total number of polymer chains	4
Total formula weight	175871.17
Authors	Zhang, Y.,Justin, N.,Wilson, J.,Gamblin, S. (deposition date: 2016-10-21, release date: 2017-01-11, Last modification date: 2025-04-09)
Primary citation	Zhang, Y.,Justin, N.,Wilson, J.R.,Gamblin, S.J. Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2". Science, 354:1543-1543, 2016 Cited by PubMed Abstract: Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect. PubMed: 28008037 DOI: 10.1126/science.aaf6236 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation