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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5M5G

Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		putative polycomb protein EEDpolymer60566021.41UniProt (G0S8H7)
Pfam (PF00400)
Pfam (PF22038)		Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
2B
(B)		Putative uncharacterized proteinpolymer937106869.61UniProt (G0SDW4)
Pfam (PF18601)
Pfam (PF18600)
Pfam (PF21509)
Pfam (PF00856)		Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
3C
(D)		HISTONE H3 11-Mer peptidepolymer111146.41UniProt (by SIFTS) (P68431)Homo sapiens
4D
(E)		Fragment from molecular 2 (region containing putative polycomb protein Suz12)polymer9926.21UniProt (by SIFTS) (G0RYC6)Chaetomium thermophilum var. thermophilum DSM 1495
5E, F, G, H, I...
(B)		ZINC IONnon-polymer65.48Chemie (ZN)
6M
(B)		S-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.41Chemie (SAH)
7N, O, P, Q
(A, B, D, E)		waterwater18.0528Chemie (HOH)
Sequence modifications
A: 1 - 565 (UniProt: G0S8H7)
PDBExternal DatabaseDetails
Met -39-initiating methionine
Ala -38-expression tag
Ser -37-expression tag
Ala -36-expression tag
Trp -35-expression tag
Ser -34-expression tag
His -33-expression tag
Pro -32-expression tag
Gln -31-expression tag
Phe -30-expression tag
Glu -29-expression tag
Lys -28-expression tag
Gly -27-expression tag
Gly -26-expression tag
Gly -25-expression tag
Ser -24-expression tag
Gly -23-expression tag
Gly -22-expression tag
Gly -21-expression tag
Ser -20-expression tag
Gly -19-expression tag
Gly -18-expression tag
Ser -17-expression tag
Ala -16-expression tag
Trp -15-expression tag
Ser -14-expression tag
His -13-expression tag
Pro -12-expression tag
Gln -11-expression tag
Phe -10-expression tag
Glu -9-expression tag
Lys -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Val -5-expression tag
Leu -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Pro 0-expression tag
B: 191 - 2525 (UniProt: G0SDW4)
PDBExternal DatabaseDetails
Ser 182-expression tag
Asn 183-expression tag
His 184-expression tag
His 185-expression tag
His 186-expression tag
His 187-expression tag
His 188-expression tag
His 189-expression tag
Ala 190-expression tag
Leu 2524Ala 951conflict
Val 2525Ala 952conflict
Pro 2526-expression tag
Arg 2527-expression tag
Gly 2528-expression tag
Ser 2529-expression tag
Glu 2530-expression tag
Val 2531-expression tag
Met 2532-expression tag
Leu 2533-expression tag
Pro 2534-expression tag
Gly 2535-expression tag
Arg 2536-expression tag
Gly 2537-expression tag
Val 2538-expression tag
Pro 2539-expression tag
Lys 2540-expression tag
Lys 2541-expression tag
Pro 2542-expression tag
Leu 2543-expression tag
Arg 2544-expression tag
Arg 2545-expression tag
Pro 2546-expression tag
Lys 2547-expression tag
Arg 2548-expression tag
Arg 2549-expression tag
Pro 2550-expression tag
Leu 2551-expression tag
Leu 2552-expression tag
Val 2553-expression tag
Pro 2554-expression tag
Lys 2555-expression tag
Thr 2556-expression tag
Thr 2557-expression tag
Gln 2558-expression tag
Pro 2559-expression tag
Leu 2560-expression tag
Phe 2561-expression tag
Asp 2562-expression tag
Pro 2563-expression tag
Leu 2564-expression tag
Ser 2565-expression tag
Lys 2566-expression tag
Val 2567-expression tag
Gln 2568-expression tag
Leu 2569-expression tag
Leu 2570-expression tag
Pro 2571-expression tag
Gly 2572-expression tag
Gln 2573-expression tag
Pro 2574-expression tag
Leu 2575-expression tag
Pro 2576-expression tag
Gln 2577-expression tag
His 2578-expression tag
Pro 2579-expression tag
Ile 2580-expression tag
Asp 2581-expression tag
Asp 2582-expression tag
Ser 2583-expression tag
Trp 2584-expression tag
Leu 2585-expression tag
Leu 2586-expression tag
Leu 2587-expression tag
Lys 2588-expression tag
His 2589-expression tag
Arg 2590-expression tag
Asp 2591-expression tag
Asn 2592-expression tag
Leu 2593-expression tag
Gln 2594-expression tag
Asp 2595-expression tag
Phe 2596-expression tag
Ile 2597-expression tag
Asp 2598-expression tag
Leu 2599-expression tag
Arg 2600-expression tag
Pro 2601-expression tag
Glu 2602-expression tag
Glu 2603-expression tag
Lys 2604-expression tag
Glu 2605-expression tag
Phe 2606-expression tag
Leu 2607-expression tag
Gln 2608-expression tag
Glu 2609-expression tag
Trp 2610-expression tag
Asp 2611-expression tag
Ala 2612-expression tag
Phe 2613-expression tag
Ile 2614-expression tag
Leu 2615-expression tag
Arg 2616-expression tag
Arg 2617-expression tag
His 2618-expression tag
Ile 2619-expression tag
Ser 2620-expression tag
Ser 2621-expression tag
Glu 2622-expression tag
Gln 2623-expression tag
Tyr 2624-expression tag
Leu 2625-expression tag
Pro 2626-expression tag
Arg 2627-expression tag
Tyr 2628-expression tag
Phe 2629-expression tag
Leu 2630-expression tag
Arg 2631-expression tag
Phe 2632-expression tag
Val 2633-expression tag
Arg 2634-expression tag
Glu 2635-expression tag
Lys 2636-expression tag
Ala 2637-expression tag
Asp 2638-expression tag
Trp 2639-expression tag
Leu 2640-expression tag
Val 2641-expression tag
Ser 2642-expression tag
Lys 2643-expression tag
Arg 2644-expression tag
Ser 2645-expression tag
Arg 2646-expression tag
Gly 2647-expression tag
Glu 2648-expression tag
Glu 2649-expression tag
Phe 2650-expression tag
Ser 2651-expression tag
Lys 2652-expression tag
Leu 2653-expression tag
Val 2654-expression tag
Ala 2655-expression tag
Thr 2656-expression tag
Leu 2657-expression tag
Leu 2658-expression tag
Ala 2659-expression tag
Arg 2660-expression tag
Arg 2661-expression tag
Val 2662-expression tag
Leu 2663-expression tag
Pro 2664-expression tag
Glu 2665-expression tag
Arg 2666-expression tag
Val 2667-expression tag
Val 2668-expression tag
Ile 2669-expression tag
Glu 2670-expression tag
Ala 2671-expression tag
Thr 2672-expression tag
Gln 2673-expression tag
Val 2674-expression tag
Leu 2675-expression tag
Asn 2676-expression tag
Asp 2677-expression tag
Ala 2678-expression tag
Arg 2679-expression tag
Gly 2680-expression tag
Arg 2681-expression tag
Leu 2682-expression tag
Arg 2683-expression tag
Glu 2684-expression tag
Gln 2685-expression tag
Gly 2686-expression tag
Gly 2687-expression tag
Val 2688-expression tag
Ile 2689-expression tag
Glu 2690-expression tag
Gly 2691-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight174963.5
Non-Polymers*Number of molecules9
Total formula weight907.7
All*Total formula weight175871.2
*Water molecules are not included.

250835

PDB entries from 2026-03-18

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