6UXX

PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 1a

Summary for 6UXX

• Entry DOI: 10.2210/pdb6uxx/pdb
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, (5R)-2-amino-5-(4-methoxyphenyl)-3-methyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-yl]-3,5-dihydro-4H-imidazol-4-one, ... (4 entities in total)
• Functional Keywords: methyltransferase, prmt5, protein arginine methyltransferase 5, allosteric inhibition, peptide competitive, sam competitive, transferase, transferase-transcription complex, transferase/transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 111979.49

Authors

Palte, R.L.,Schneider, S.E. (deposition date: 2019-11-08, release date: 2020-08-19, Last modification date: 2023-10-11)

• Primary citation: Palte, R.L.,Schneider, S.E.,Altman, M.D.,Hayes, R.P.,Kawamura, S.,Lacey, B.M.,Mansueto, M.S.,Reutershan, M.,Siliphaivanh, P.,Sondey, C.,Xu, H.,Xu, Z.,Ye, Y.,Machacek, M.R.; Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).; Acs Med.Chem.Lett., 11:1688-1693, 2020; PubMed: 32944135; DOI: 10.1021/acsmedchemlett.9b00525

Experimental method

X-RAY DIFFRACTION (2.69 Å)