7QJU
EED in complex with PRC2 allosteric inhibitor compound 7
Summary for 7QJU
Entry DOI | 10.2210/pdb7qju/pdb |
Related | 7QJG |
Descriptor | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 92641.23 |
Authors | Zhao, K.,Zhao, M.,Luo, X.,Zhang, H.,Scheufler, C. (deposition date: 2021-12-17, release date: 2022-04-13, Last modification date: 2024-01-31) |
Primary citation | Huang, Y.,Sendzik, M.,Zhang, J.,Gao, Z.,Sun, Y.,Wang, L.,Gu, J.,Zhao, K.,Yu, Z.,Zhang, L.,Zhang, Q.,Blanz, J.,Chen, Z.,Dubost, V.,Fang, D.,Feng, L.,Fu, X.,Kiffe, M.,Li, L.,Luo, F.,Luo, X.,Mi, Y.,Mistry, P.,Pearson, D.,Piaia, A.,Scheufler, C.,Terranova, R.,Weiss, A.,Zeng, J.,Zhang, H.,Zhang, J.,Zhao, M.,Dillon, M.P.,Jeay, S.,Qi, W.,Moggs, J.,Pissot-Soldermann, C.,Li, E.,Atadja, P.,Lingel, A.,Oyang, C. Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. J.Med.Chem., 65:5317-5333, 2022 Cited by PubMed: 35352560DOI: 10.1021/acs.jmedchem.1c02148 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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