7QJG

EED in complex with PRC2 allosteric inhibitor compound 6

Summary for 7QJG

• Entry DOI: 10.2210/pdb7qjg/pdb
• Descriptor: Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 92641.23

Authors

Zhao, K.,Zhao, M.,Luo, X.,Zhang, H.,Scheufler, C. (deposition date: 2021-12-16, release date: 2022-04-13, Last modification date: 2024-01-31)

• Primary citation: Huang, Y.,Sendzik, M.,Zhang, J.,Gao, Z.,Sun, Y.,Wang, L.,Gu, J.,Zhao, K.,Yu, Z.,Zhang, L.,Zhang, Q.,Blanz, J.,Chen, Z.,Dubost, V.,Fang, D.,Feng, L.,Fu, X.,Kiffe, M.,Li, L.,Luo, F.,Luo, X.,Mi, Y.,Mistry, P.,Pearson, D.,Piaia, A.,Scheufler, C.,Terranova, R.,Weiss, A.,Zeng, J.,Zhang, H.,Zhang, J.,Zhao, M.,Dillon, M.P.,Jeay, S.,Qi, W.,Moggs, J.,Pissot-Soldermann, C.,Li, E.,Atadja, P.,Lingel, A.,Oyang, C.; Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.; J.Med.Chem., 65:5317-5333, 2022; PubMed: 35352560; DOI: 10.1021/acs.jmedchem.1c02148

Experimental method

X-RAY DIFFRACTION (1.8 Å)