7QJG
EED in complex with PRC2 allosteric inhibitor compound 6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Polycomb protein EED | polymer | 366 | 42227.1 | 2 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 2 | C, D (C, D) | Histone-lysine N-methyltransferase EZH2 | polymer | 29 | 3622.2 | 2 | UniProt (Q15910) Pfam (PF11616) | Homo sapiens | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 3 | E, F, H, I (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | G, J (A, B) | N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | non-polymer | 400.5 | 2 | Chemie (EKR) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 398 | Chemie (HOH) |
Sequence modifications
A, B: 77 - 441 (UniProt: O75530)
| PDB | External Database | Details |
|---|---|---|
| Gly 76 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 91698.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 942.8 | |
| All* | Total formula weight | 92641.2 |
