6OT0

Structure of human Smoothened-Gi complex

Summary for 6OT0

• Entry DOI: 10.2210/pdb6ot0/pdb
• EMDB information: 20190
• Descriptor: Smoothened homolog, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• Functional Keywords: gpcr, complex, hedgehog signaling, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 198577.19

Authors

Qi, X.,Li, X. (deposition date: 2019-05-02, release date: 2019-06-12, Last modification date: 2019-12-18)

• Primary citation: Qi, X.,Liu, H.,Thompson, B.,McDonald, J.,Zhang, C.,Li, X.; Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.; Nature, 571:279-283, 2019; PubMed: 31168089; DOI: 10.1038/s41586-019-1286-0

Experimental method

ELECTRON MICROSCOPY (3.9 Å)