6OT0
Structure of human Smoothened-Gi complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Smoothened homolog | polymer | 563 | 62109.4 | 1 | UniProt (Q99835) Pfam (PF01392) Pfam (PF01534) In PDB | Homo sapiens (Human) | SMO,Protein Gx |
2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
5 | L | Fab light chain | polymer | 215 | 23258.8 | 1 | Mus musculus (Mouse) | ||
6 | H | Fab heavy chain | polymer | 239 | 25788.8 | 1 | Mus musculus (Mouse) | ||
7 | R | 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL | non-polymer | 400.6 | 1 | Chemie (CO1) |
Sequence modifications
R: 1 - 555 (UniProt: Q99835)
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Asp 556 | - | expression tag |
Tyr 557 | - | expression tag |
Lys 558 | - | expression tag |
Asp 559 | - | expression tag |
Asp 560 | - | expression tag |
Asp 561 | - | expression tag |
Asp 562 | - | expression tag |
Lys 563 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | conflict |
Ala 203 | Gly 203 | conflict |
Ala 245 | Glu 245 | conflict |
Ser 326 | Ala 326 | conflict |
PDB | External Database | Details |
---|---|---|
Met -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 198176.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 400.6 | |
All* | Total formula weight | 198577.2 |