6V0O

PRMT5 bound to the PBM peptide from pICln

Summary for 6V0O

• Entry DOI: 10.2210/pdb6v0o/pdb
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, PBM peptide, ... (5 entities in total)
• Functional Keywords: methylation, methyltransferase, epigenetic, sdma, splicing, transferase-splicing complex, transferase/splicing
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 111319.68

Authors

McMillan, B.J.,Raymond, D.D. (deposition date: 2019-11-19, release date: 2020-08-26, Last modification date: 2023-10-11)

• Primary citation: Mulvaney, K.M.,Blomquist, C.,Acharya, N.,Li, R.,Ranaghan, M.J.,O'Keefe, M.,Rodriguez, D.J.,Young, M.J.,Kesar, D.,Pal, D.,Stokes, M.,Nelson, A.J.,Jain, S.S.,Yang, A.,Mullin-Bernstein, Z.,Columbus, J.,Bozal, F.K.,Skepner, A.,Raymond, D.,LaRussa, S.,McKinney, D.C.,Freyzon, Y.,Baidi, Y.,Porter, D.,Aguirre, A.J.,Ianari, A.,McMillan, B.,Sellers, W.R.; Molecular basis for substrate recruitment to the PRMT5 methylosome.; Mol.Cell, 81:3481-, 2021; PubMed: 34358446; DOI: 10.1016/j.molcel.2021.07.019

Experimental method

X-RAY DIFFRACTION (2.86 Å)