PDB: 1205 件ウェブページステータス検索Chemie searchBIRD

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7XT8	Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. 登録日 2022-05-16 公開日 2022-07-27 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
7XTC	Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex 分子名称: 3-(2-azanylethyl)-1H-indole-5-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. 登録日 2022-05-16 公開日 2022-07-27 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
7XT9	Serotonin 4 (5-HT4) receptor-Gs complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. 登録日 2022-05-16 公開日 2022-07-27 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
7XTA	Serotonin 4 (5-HT4) receptor-Gi-scFv16 complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. 登録日 2022-05-16 公開日 2022-07-27 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
7SK8	Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab 分子名称: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Atypical chemokine receptor 3, CHOLESTEROL, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7SK5	Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab 分子名称: Anti-Fab nanobody, Atypical chemokine receptor 3, CHOLESTEROL, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7SK7	Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, and an extracellular Fab 分子名称: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Anti-Fab nanobody, Atypical chemokine receptor 3, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7SK3	Cryo-EM structure of ACKR3 in complex with CXCL12, an intracellular Fab, and an extracellular Fab 分子名称: Atypical chemokine receptor 3, CHOLESTEROL, CID24 Fab heavy chain, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7SK6	Cryo-EM structure of human ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ and an intracellular Fab 分子名称: Atypical chemokine receptor 3, CID24 Fab heavy chain, CID24 Fab light chain, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7SK4	Cryo-EM structure of ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ, an intracellular Fab, and an extracellular Fab 分子名称: Atypical chemokine receptor 3, CHOLESTEROL, CID24 Fab heavy chain, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7SK9	Cryo-EM structure of human ACKR3 in complex with a small molecule partial agonist CCX662, and an intracellular Fab 分子名称: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Atypical chemokine receptor 3, CHOLESTEROL, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7XOU	Structural insights into human brain gut peptide cholecystokinin receptors 分子名称: CCK-8, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. 登録日 2022-05-01 公開日 2022-07-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insights into human brain-gut peptide cholecystokinin receptors. Cell Discov, 8, 2022
7XOW	Structural insights into human brain gut peptide cholecystokinin receptors 分子名称: Gastrin, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. 登録日 2022-05-01 公開日 2022-07-20 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into human brain-gut peptide cholecystokinin receptors. Cell Discov, 8, 2022
7XOV	Structural insights into human brain gut peptide cholecystokinin receptors 分子名称: 2-[2-[[4-(4-chloranyl-2,5-dimethoxy-phenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethyl-indol-1-yl]ethanoic acid, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. 登録日 2022-05-01 公開日 2022-07-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into human brain-gut peptide cholecystokinin receptors. Cell Discov, 8, 2022
7UM5	CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT 分子名称: 3-(2-azanylethyl)-1H-indole-5-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, S, Fay, J.F, Roth, B.L. 登録日 2022-04-06 公開日 2022-07-20 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (2.73 Å) 主引用文献 Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
7UM4	Crystal structure of inactive 5-HT5AR in complex with AS2674723 分子名称: 5-hydroxytryptamine receptor 5A, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ... 著者 Zhang, S, Roth, B.L. 登録日 2022-04-06 公開日 2022-07-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
7UM6	CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride 分子名称: 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, S, Fay, J.F, Roth, B.L. 登録日 2022-04-06 公開日 2022-07-20 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (2.79 Å) 主引用文献 Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
7UM7	CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine 分子名称: (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, S, Fay, J.F, Roth, B.L. 登録日 2022-04-06 公開日 2022-07-20 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (2.75 Å) 主引用文献 Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
7Y15	Cryo-EM structure of apo-state MrgD-Gi complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. 登録日 2022-06-06 公開日 2022-07-20 最終更新日 2022-11-23 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
7Y12	Cryo-EM structure of MrgD-Gi complex with beta-alanine 分子名称: BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. 登録日 2022-06-06 公開日 2022-07-20 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
7Y14	Cryo-EM structure of MrgD-Gi complex with beta-alanine (local) 分子名称: BETA-ALANINE, PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D 著者 Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. 登録日 2022-06-06 公開日 2022-07-20 最終更新日 2022-11-23 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
7Y13	Cryo-EM structure of apo-state MrgD-Gi complex (local) 分子名称: PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D 著者 Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. 登録日 2022-06-06 公開日 2022-07-20 最終更新日 2022-11-23 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
7XBD	Cryo-EM structure of human galanin receptor 2 分子名称: Galanin, Galanin receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ishimoto, N, Kita, S, Park, S.Y. 登録日 2022-03-21 公開日 2022-07-13 最終更新日 2022-08-10 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface. Plos Biol., 20, 2022
7XBW	Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with Gi1 分子名称: CHOLESTEROL, CX3C chemokine receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. 登録日 2022-03-22 公開日 2022-07-13 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
7XBX	Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. 登録日 2022-03-22 公開日 2022-07-13 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022

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