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7SK9
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Cryo-EM structure of human ACKR3 in complex with a small molecule partial agonist CCX662, and an intracellular Fab
分子名称: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Atypical chemokine receptor 3, CHOLESTEROL, ...
著者Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
登録日2021-10-19
公開日2022-07-27
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK3
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BU of 7sk3 by Molmil
Cryo-EM structure of ACKR3 in complex with CXCL12, an intracellular Fab, and an extracellular Fab
分子名称: Atypical chemokine receptor 3, CHOLESTEROL, CID24 Fab heavy chain, ...
著者Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
登録日2021-10-19
公開日2022-07-27
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK8
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BU of 7sk8 by Molmil
Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab
分子名称: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Atypical chemokine receptor 3, CHOLESTEROL, ...
著者Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
登録日2021-10-19
公開日2022-07-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK5
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BU of 7sk5 by Molmil
Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab
分子名称: Anti-Fab nanobody, Atypical chemokine receptor 3, CHOLESTEROL, ...
著者Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
登録日2021-10-19
公開日2022-07-27
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK7
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BU of 7sk7 by Molmil
Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, and an extracellular Fab
分子名称: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Anti-Fab nanobody, Atypical chemokine receptor 3, ...
著者Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
登録日2021-10-19
公開日2022-07-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7XTB
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BU of 7xtb by Molmil
Serotonin 6 (5-HT6) receptor-Gs-Nb35 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XTC
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BU of 7xtc by Molmil
Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex
分子名称: 3-(2-azanylethyl)-1H-indole-5-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XTA
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BU of 7xta by Molmil
Serotonin 4 (5-HT4) receptor-Gi-scFv16 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XT8
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BU of 7xt8 by Molmil
Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XT9
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BU of 7xt9 by Molmil
Serotonin 4 (5-HT4) receptor-Gs complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7SUS
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BU of 7sus by Molmil
Crystal structure of Apelin receptor in complex with small molecule
分子名称: (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Apelin receptor, ...
著者Xu, F, Yue, Y, Liu, L.E, Han, G.W, Hanson, M.
登録日2021-11-18
公開日2022-07-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
7XOW
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BU of 7xow by Molmil
Structural insights into human brain gut peptide cholecystokinin receptors
分子名称: Gastrin, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S.
登録日2022-05-01
公開日2022-07-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
7XOU
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BU of 7xou by Molmil
Structural insights into human brain gut peptide cholecystokinin receptors
分子名称: CCK-8, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S.
登録日2022-05-01
公開日2022-07-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
7XOV
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BU of 7xov by Molmil
Structural insights into human brain gut peptide cholecystokinin receptors
分子名称: 2-[2-[[4-(4-chloranyl-2,5-dimethoxy-phenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethyl-indol-1-yl]ethanoic acid, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S.
登録日2022-05-01
公開日2022-07-20
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
7Y13
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BU of 7y13 by Molmil
Cryo-EM structure of apo-state MrgD-Gi complex (local)
分子名称: PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D
著者Suzuki, S, Iida, M, Kawamoto, A, Oshima, A.
登録日2022-06-06
公開日2022-07-20
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
7Y14
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BU of 7y14 by Molmil
Cryo-EM structure of MrgD-Gi complex with beta-alanine (local)
分子名称: BETA-ALANINE, PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D
著者Suzuki, S, Iida, M, Kawamoto, A, Oshima, A.
登録日2022-06-06
公開日2022-07-20
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
7Y12
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BU of 7y12 by Molmil
Cryo-EM structure of MrgD-Gi complex with beta-alanine
分子名称: BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Suzuki, S, Iida, M, Kawamoto, A, Oshima, A.
登録日2022-06-06
公開日2022-07-20
最終更新日2023-02-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
7UM7
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BU of 7um7 by Molmil
CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine
分子名称: (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhang, S, Fay, J.F, Roth, B.L.
登録日2022-04-06
公開日2022-07-20
最終更新日2022-07-27
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
Nat.Struct.Mol.Biol., 29, 2022
7Y15
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BU of 7y15 by Molmil
Cryo-EM structure of apo-state MrgD-Gi complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Suzuki, S, Iida, M, Kawamoto, A, Oshima, A.
登録日2022-06-06
公開日2022-07-20
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
7UM5
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BU of 7um5 by Molmil
CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT
分子名称: 3-(2-azanylethyl)-1H-indole-5-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhang, S, Fay, J.F, Roth, B.L.
登録日2022-04-06
公開日2022-07-20
最終更新日2022-07-27
実験手法ELECTRON MICROSCOPY (2.73 Å)
主引用文献Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
Nat.Struct.Mol.Biol., 29, 2022
7UM4
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BU of 7um4 by Molmil
Crystal structure of inactive 5-HT5AR in complex with AS2674723
分子名称: 5-hydroxytryptamine receptor 5A, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ...
著者Zhang, S, Roth, B.L.
登録日2022-04-06
公開日2022-07-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
Nat.Struct.Mol.Biol., 29, 2022
7UM6
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BU of 7um6 by Molmil
CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride
分子名称: 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhang, S, Fay, J.F, Roth, B.L.
登録日2022-04-06
公開日2022-07-20
最終更新日2022-07-27
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
Nat.Struct.Mol.Biol., 29, 2022
7XBX
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BU of 7xbx by Molmil
Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q.
登録日2022-03-22
公開日2022-07-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.
Sci Adv, 8, 2022
7WJ5
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BU of 7wj5 by Molmil
Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity
分子名称: Gai1 antibody (scfv16), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Heo, Y.S, Yoon, E.J, Jeon, Y.E, Yun, J.-H, Ishimoto, N, Woo, H, Park, S.Y, Song, J, Lee, W.T.
登録日2022-01-05
公開日2022-07-13
実験手法ELECTRON MICROSCOPY (3.72 Å)
主引用文献Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity.
Elife, 11, 2022
7XBD
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BU of 7xbd by Molmil
Cryo-EM structure of human galanin receptor 2
分子名称: Galanin, Galanin receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Ishimoto, N, Kita, S, Park, S.Y.
登録日2022-03-21
公開日2022-07-13
最終更新日2022-08-10
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
Plos Biol., 20, 2022

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件を2024-06-26に公開中

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