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7WCM
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Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
分子名称: 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Qiao, A.N, Wu, S, Ye, S.
登録日2021-12-20
公開日2022-12-21
最終更新日2022-12-28
実験手法ELECTRON MICROSCOPY (2.33 Å)
主引用文献Activation and signaling mechanism revealed by GPR119-G s complex structures.
Nat Commun, 13, 2022
6B20
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Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator
分子名称: CHLORIDE ION, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
著者Gulati, S, Kiser, P.D, Palczewski, K.
登録日2017-09-19
公開日2018-05-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.
Nat Commun, 9, 2018
9AUC
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Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin gene-related peptide 1, ...
著者Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M.
登録日2024-02-28
公開日2024-04-24
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.
Biochemistry, 63, 2024
6UUS
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CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide
分子名称: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
登録日2019-10-31
公開日2020-04-01
最終更新日2020-04-29
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
2TRC
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PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
分子名称: GADOLINIUM ATOM, PHOSDUCIN, TRANSDUCIN
著者Gaudet, R, Bohm, A, Sigler, P.B.
登録日1997-01-06
公開日1997-06-05
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin.
Cell(Cambridge,Mass.), 87, 1996
7XKF
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BU of 7xkf by Molmil
Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex at lower state
分子名称: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, Adhesion G-protein coupled receptor G2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Guo, S.C, Xiao, P, Lin, H, Sun, J.P, Yu, X.
登録日2022-04-19
公開日2022-08-10
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structures of the ADGRG2-G s complex in apo and ligand-bound forms.
Nat.Chem.Biol., 18, 2022
7XKD
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Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex
分子名称: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, Adhesion G-protein coupled receptor G2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Guo, S.C, Xiao, P, Lin, H, Sun, J.P, Yu, X.
登録日2022-04-19
公開日2022-08-10
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structures of the ADGRG2-G s complex in apo and ligand-bound forms.
Nat.Chem.Biol., 18, 2022
7TZF
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Human Amylin3 Receptor in complex with Gs and rat amylin peptide
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-15
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
1GG2
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G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND
分子名称: G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, ...
著者Wall, M.A, Sprang, S.R.
登録日1996-11-13
公開日1997-02-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
Cell(Cambridge,Mass.), 83, 1995
8PJK
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ST171-bound serotonin 5-HT1A receptor - Gi Protein Complex
分子名称: (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 5-hydroxytryptamine receptor 1A, 6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{H}-1,4-benzoxazin-3-one, ...
著者Schneider, J, Gmeiner, P, Rasmussen, T, Boettcher, B.
登録日2023-06-23
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Discovery of a functionally selective serotonin 1A receptor agonist for the treatment of pain
To Be Published
7TRP
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Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298
分子名称: 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ...
著者Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M.
登録日2022-01-30
公開日2023-05-17
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor
Elife, 2023
7UTZ
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BU of 7utz by Molmil
Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
分子名称: (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain analog TR1402, ...
著者Faust, B, Cheng, Y, Manglik, A.
登録日2022-04-28
公開日2022-08-03
最終更新日2022-10-05
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
7EJX
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BU of 7ejx by Molmil
Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand
分子名称: (1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Xu, J, Chen, G, Liu, Z, Du, Y.
登録日2021-04-02
公開日2022-04-13
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.
Nat Commun, 13, 2022
4MK0
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BU of 4mk0 by Molmil
Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
分子名称: 5-{[(3S,4R)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-1H-isoindol-1-one, Beta-adrenergic receptor kinase 1, GLYCEROL, ...
著者Homan, K.T, Tesmer, J.J.G.
登録日2013-09-04
公開日2014-01-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.
Mol.Pharmacol., 85, 2014
8X79
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MRE-269 bound Prostacyclin Receptor G protein complex
分子名称: 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C.
登録日2023-11-23
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (2.41 Å)
主引用文献Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs.
Sci Adv, 10, 2024
7S1M
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BU of 7s1m by Molmil
Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 1)
分子名称: Ex4-D-Ala, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cary, B.P, Gellman, S.H.
登録日2021-09-02
公開日2022-01-05
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (2.41 Å)
主引用文献Structural and functional diversity among agonist-bound states of the GLP-1 receptor.
Nat.Chem.Biol., 18, 2022
6U7C
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Human GRK2 in complex with Gbetagamma subunits and CCG258747
分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(2H-indazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Bouley, R, Tesmer, J.J.G.
登録日2019-09-02
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor.
Mol.Pharmacol., 97, 2020
7MBY
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Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex
分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ...
著者Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M.
登録日2021-04-01
公開日2021-05-26
最終更新日2021-07-14
実験手法ELECTRON MICROSCOPY (2.44 Å)
主引用文献Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Plos Biol., 19, 2021
8FX5
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Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline
分子名称: Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Vuckovic, Z, Mobbs, J.I, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M.
登録日2023-01-23
公開日2023-09-13
実験手法ELECTRON MICROSCOPY (2.45 Å)
主引用文献Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR.
Nat Commun, 14, 2023
7S8L
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CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14
分子名称: Cortistatin 14, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L.
登録日2021-09-18
公開日2021-11-17
最終更新日2021-12-15
実験手法ELECTRON MICROSCOPY (2.45 Å)
主引用文献Structure, function and pharmacology of human itch GPCRs.
Nature, 600, 2021
8JIS
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Cryo-EM structure of the GLP-1R/GCGR dual agonist peptide15-bound human GLP-1R-Gs complex
分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T.
登録日2023-05-27
公開日2023-11-08
実験手法ELECTRON MICROSCOPY (2.46 Å)
主引用文献Structural analysis of the dual agonism at GLP-1R and GCGR.
Proc.Natl.Acad.Sci.USA, 120, 2023
8YKV
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Cryo-EM structure of succinate receptor SUCR1 bound to compound 31
分子名称: (2~{S})-2-[[6-[4-(trifluoromethyloxy)phenyl]pyridin-2-yl]carbonylamino]butanedioic acid, Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E.
登録日2024-03-05
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (2.48 Å)
主引用文献Cryo-EM structure of succinate receptor SUCR1 bound to compound 31
To Be Published
3PVU
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Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)
分子名称: 3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Thal, D.M, Tesmer, J.J.
登録日2010-12-07
公開日2011-06-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
3PVW
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Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A)
分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Thal, D.M, Tesmer, J.J.
登録日2010-12-07
公開日2011-06-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
7T10
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CryoEM structure of somatostatin receptor 2 in complex with somatostatin-14 and Gi3
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ...
著者Robertson, M.J, Skinotis, G.
登録日2021-11-30
公開日2022-03-09
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Plasticity in ligand recognition at somatostatin receptors.
Nat.Struct.Mol.Biol., 29, 2022

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