7S1M

Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 1)

Summary for 7S1M

• Entry DOI: 10.2210/pdb7s1m/pdb
• EMDB information: 24805
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: glucagon, glp-1, exendin, g protein, gdp, gtp, complex, agonist, d-alanine, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 164328.10

Authors

Cary, B.P.,Gellman, S.H. (deposition date: 2021-09-02, release date: 2022-01-05, Last modification date: 2022-03-16)

• Primary citation: Cary, B.P.,Deganutti, G.,Zhao, P.,Truong, T.T.,Piper, S.J.,Liu, X.,Belousoff, M.J.,Danev, R.,Sexton, P.M.,Wootten, D.,Gellman, S.H.; Structural and functional diversity among agonist-bound states of the GLP-1 receptor.; Nat.Chem.Biol., 18:256-263, 2022; PubMed: 34937906; DOI: 10.1038/s41589-021-00945-w

Experimental method

ELECTRON MICROSCOPY (2.41 Å)