7UTZ

Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)

Summary for 7UTZ

Entry DOI	10.2210/pdb7utz/pdb
EMDB information	26795
Descriptor	Glycoprotein hormones alpha chain analog TR1402, Thyrotropin subunit beta, Nanobody 35, ... (9 entities in total)
Functional Keywords	g protein-coupled receptor, thyroid-stimulating hormone receptor, thyrotropin receptor, tsh, thyroid, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	7
Total formula weight	199221.47
Authors	Faust, B.,Cheng, Y.,Manglik, A. (deposition date: 2022-04-28, release date: 2022-08-03, Last modification date: 2022-10-05)
Primary citation	Faust, B.,Billesbolle, C.B.,Suomivuori, C.M.,Singh, I.,Zhang, K.,Hoppe, N.,Pinto, A.F.M.,Diedrich, J.K.,Muftuoglu, Y.,Szkudlinski, M.W.,Saghatelian, A.,Dror, R.O.,Cheng, Y.,Manglik, A. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609:846-853, 2022 Cited by PubMed: 35940205 DOI: 10.1038/s41586-022-05159-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.4 Å)

Structure validation