Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7UTZ

Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005796	cellular_component	Golgi lumen
A	0006590	biological_process	thyroid hormone generation
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008406	biological_process	gonad development
A	0009755	biological_process	hormone-mediated signaling pathway
A	0010469	biological_process	regulation of signaling receptor activity
A	0010893	biological_process	positive regulation of steroid biosynthetic process
A	0016913	molecular_function	follicle-stimulating hormone activity
A	0016914	cellular_component	follicle-stimulating hormone complex
A	0030335	biological_process	positive regulation of cell migration
A	0030878	biological_process	thyroid gland development
A	0032275	biological_process	luteinizing hormone secretion
A	0032870	biological_process	cellular response to hormone stimulus
A	0035265	biological_process	organ growth
A	0042699	biological_process	follicle-stimulating hormone signaling pathway
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046621	biological_process	negative regulation of organ growth
A	0046884	biological_process	follicle-stimulating hormone secretion
A	0048589	biological_process	developmental growth
A	0061696	cellular_component	pituitary gonadotropin complex
B	0005102	molecular_function	signaling receptor binding
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007267	biological_process	cell-cell signaling
B	0009653	biological_process	anatomical structure morphogenesis
R	0004930	molecular_function	G protein-coupled receptor activity
R	0004996	molecular_function	thyroid-stimulating hormone receptor activity
R	0005515	molecular_function	protein binding
R	0005886	cellular_component	plasma membrane
R	0007165	biological_process	signal transduction
R	0007166	biological_process	cell surface receptor signaling pathway
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007187	biological_process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
R	0007267	biological_process	cell-cell signaling
R	0008284	biological_process	positive regulation of cell population proliferation
R	0008528	molecular_function	G protein-coupled peptide receptor activity
R	0009725	biological_process	response to hormone
R	0009755	biological_process	hormone-mediated signaling pathway
R	0009986	cellular_component	cell surface
R	0016020	cellular_component	membrane
R	0016323	cellular_component	basolateral plasma membrane
R	0016500	molecular_function	protein-hormone receptor activity
R	0038023	molecular_function	signaling receptor activity
R	0038194	biological_process	thyroid-stimulating hormone signaling pathway
R	0043235	cellular_component	receptor complex
R	0044877	molecular_function	protein-containing complex binding
R	0120162	biological_process	positive regulation of cold-induced thermogenesis
R	1904588	biological_process	cellular response to glycoprotein
R	1905229	biological_process	cellular response to thyrotropin-releasing hormone
X	0003924	molecular_function	GTPase activity
X	0005525	molecular_function	GTP binding
X	0007186	biological_process	G protein-coupled receptor signaling pathway
X	0019001	molecular_function	guanyl nucleotide binding
X	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
Y	0001750	cellular_component	photoreceptor outer segment
Y	0003924	molecular_function	GTPase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005765	cellular_component	lysosomal membrane
Y	0005829	cellular_component	cytosol
Y	0005834	cellular_component	heterotrimeric G-protein complex
Y	0005886	cellular_component	plasma membrane
Y	0007165	biological_process	signal transduction
Y	0007186	biological_process	G protein-coupled receptor signaling pathway
Y	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
Y	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
Y	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
Y	0007265	biological_process	Ras protein signal transduction
Y	0008283	biological_process	cell population proliferation
Y	0016020	cellular_component	membrane
Y	0030159	molecular_function	signaling receptor complex adaptor activity
Y	0044877	molecular_function	protein-containing complex binding
Y	0045202	cellular_component	synapse
Y	0050909	biological_process	sensory perception of taste
Y	0051020	molecular_function	GTPase binding
Y	0060041	biological_process	retina development in camera-type eye
Y	0070062	cellular_component	extracellular exosome
Y	0071380	biological_process	cellular response to prostaglandin E stimulus
Y	0071870	biological_process	cellular response to catecholamine stimulus
Y	0097381	cellular_component	photoreceptor disc membrane
Y	1903561	cellular_component	extracellular vesicle
Z	0005515	molecular_function	protein binding
Z	0005834	cellular_component	heterotrimeric G-protein complex
Z	0005886	cellular_component	plasma membrane
Z	0007165	biological_process	signal transduction
Z	0007186	biological_process	G protein-coupled receptor signaling pathway
Z	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
Z	0016020	cellular_component	membrane
Z	0031681	molecular_function	G-protein beta-subunit binding
Z	0045202	cellular_component	synapse
Z	0048144	biological_process	fibroblast proliferation
Z	0070062	cellular_component	extracellular exosome
Z	0071380	biological_process	cellular response to prostaglandin E stimulus
Z	0071870	biological_process	cellular response to catecholamine stimulus

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. LSVyTLTVITLERWYaI

Chain	Residue	Details
R	LEU507-ILE523

site_id	PS00261
Number of Residues	7
Details	GLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CAGYCmT

Chain	Residue	Details
B	CYS27-THR33

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
Y	LEU70-SER84
Y	ILE157-ILE171
Y	LEU285-ALA299

site_id	PS00689
Number of Residues	28
Details	GLYCO_HORMONE_BETA_2 Glycoprotein hormones beta chain signature 2. PVAlsCkCgkCntdySDCiheaik..TnyC

Chain	Residue	Details
B	PRO78-CYS105

site_id	PS00779
Number of Residues	13
Details	GLYCO_HORMONE_ALPHA_1 Glycoprotein hormones alpha chain signature 1. CmGCCFSRAYPTP

Chain	Residue	Details
A	CYS28-PRO40

site_id	PS00780
Number of Residues	14
Details	GLYCO_HORMONE_ALPHA_2 Glycoprotein hormones alpha chain signature 2. NHTaChCsTCyyHK

Chain	Residue	Details
A	ASN78-LYS91

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000036","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24692546","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000037","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24692546","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	27
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	49
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	24
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	25
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	22
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	23
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	23
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	21
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	21
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"11847099","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11502179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17542669","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17542669","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11502179","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	13
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	9
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	7
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	5
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	17
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04896","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	48
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	45
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	41
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	43
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	41
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	30
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)