9AUC

Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide

Summary for 9AUC

• Entry DOI: 10.2210/pdb9auc/pdb
• EMDB information: 43877
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (11 entities in total)
• Functional Keywords: amylin receptor, gpcr, ramp3, calcitonin gene-related peptide, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 189471.23

Authors

Cao, J.,Belousoff, M.J.,Wootten, D.L.,Sexton, P.M. (deposition date: 2024-02-28, release date: 2024-04-24, Last modification date: 2024-05-22)

• Primary citation: Cao, J.,Belousoff, M.J.,Danev, R.,Christopoulos, A.,Wootten, D.,Sexton, P.M.; Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.; Biochemistry, 63:1089-1096, 2024; PubMed: 38603770; DOI: 10.1021/acs.biochem.4c00114

Experimental method

ELECTRON MICROSCOPY (2.4 Å)