5XXT
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![BU of 5xxt by Molmil](/molmil-images/mine/5xxt) | GDP-microtubule complexed with nucleotide-free KIF5C | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | 登録日 | 2017-07-05 | 公開日 | 2018-10-10 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (5.35 Å) | 主引用文献 | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport J. Cell Biol., 217, 2018
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5XP3
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![BU of 5xp3 by Molmil](/molmil-images/mine/5xp3) | Crystal structure of apo T2R-TTL | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-05-31 | 公開日 | 2017-10-25 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018
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5XLZ
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![BU of 5xlz by Molmil](/molmil-images/mine/5xlz) | |
5XLT
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![BU of 5xlt by Molmil](/molmil-images/mine/5xlt) | The crystal structure of tubulin in complex with 4'-demethylepipodophyllotoxin | 分子名称: | (5S,5aR,8aR,9R)-9-(3,5-dimethoxy-4-oxidanyl-phenyl)-5-oxidanyl-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Yu, Y, Chen, Q. | 登録日 | 2017-05-11 | 公開日 | 2017-09-27 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.813 Å) | 主引用文献 | Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design Biochem. Biophys. Res. Commun., 493, 2017
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5XKH
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![BU of 5xkh by Molmil](/molmil-images/mine/5xkh) | Crystal structure of T2R-TTL-CF1 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(4-methoxy-3-oxidanyl-phenyl)-methyl-amino]chromen-2-one, CALCIUM ION, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-05-07 | 公開日 | 2018-06-20 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors To Be Published
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5XKG
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![BU of 5xkg by Molmil](/molmil-images/mine/5xkg) | Crystal structure of T2R-TTL-CH1 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3-azanyl-4-methoxy-phenyl)-methyl-amino]chromen-2-one, CALCIUM ION, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-05-07 | 公開日 | 2018-04-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors To Be Published
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5XKF
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![BU of 5xkf by Molmil](/molmil-images/mine/5xkf) | Crystal structure of T2R-TTL-MPC6827 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-05-07 | 公開日 | 2018-04-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors To Be Published
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5XKE
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![BU of 5xke by Molmil](/molmil-images/mine/5xke) | Crystal structure of T2R-TTL-Demecolcine complex | 分子名称: | (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-05-07 | 公開日 | 2018-07-04 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors To Be Published
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5XIW
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![BU of 5xiw by Molmil](/molmil-images/mine/5xiw) | Crystal structure of T2R-TTL-Colchicine complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-04-27 | 公開日 | 2018-04-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018
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5XI7
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![BU of 5xi7 by Molmil](/molmil-images/mine/5xi7) | Crystal structure of T2R-TTL bound with PO-7 | 分子名称: | (6Z)-3-[[2,5-bis(fluoranyl)phenyl]methylidene]-6-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Chu, Y, Wang, Y, Yang, J, Li, W. | 登録日 | 2017-04-26 | 公開日 | 2017-10-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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5XI5
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![BU of 5xi5 by Molmil](/molmil-images/mine/5xi5) | Crystal structure of T2R-TTL-PO5 complex | 分子名称: | (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Chu, Y, Wang, Y, Yang, J, Li, W. | 登録日 | 2017-04-26 | 公開日 | 2017-10-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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5XHC
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![BU of 5xhc by Molmil](/molmil-images/mine/5xhc) | Crystal structure of T2R-TTL-PO10 complex | 分子名称: | (3Z,6Z)-3-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]-6-[[3-(4-fluorophenyl)carbonylphenyl]methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Chu, Y, Wang, Y, Yang, J, Li, W. | 登録日 | 2017-04-20 | 公開日 | 2017-10-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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5XDW
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![BU of 5xdw by Molmil](/molmil-images/mine/5xdw) | Staphylococcus aureus FtsZ 12-316 G196S | 分子名称: | CALCIUM ION, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | 著者 | Fujita, J, Maeda, Y, Mizohata, E, Inoue, T, Kaul, M, Parhi, A.K, LaVoie, E.J, Pilch, D.S, Matsumura, H. | 登録日 | 2017-03-30 | 公開日 | 2017-08-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ ACS Chem. Biol., 12, 2017
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5XDV
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![BU of 5xdv by Molmil](/molmil-images/mine/5xdv) | Staphylococcus aureus FtsZ 12-316 G196S complexed with TXA6101 | 分子名称: | 3-[[5-bromanyl-4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl]methoxy]-2,6-bis(fluoranyl)benzamide, CALCIUM ION, Cell division protein FtsZ, ... | 著者 | Fujita, J, Maeda, Y, Mizohata, E, Inoue, T, Kaul, M, Parhi, A.K, LaVoie, E.J, Pilch, D.S, Matsumura, H. | 登録日 | 2017-03-30 | 公開日 | 2017-08-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ ACS Chem. Biol., 12, 2017
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5XDU
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![BU of 5xdu by Molmil](/molmil-images/mine/5xdu) | Staphylococcus aureus FtsZ 12-316 complexed with TXA6101 | 分子名称: | 3-[[5-bromanyl-4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl]methoxy]-2,6-bis(fluoranyl)benzamide, CALCIUM ION, Cell division protein FtsZ, ... | 著者 | Fujita, J, Maeda, Y, Mizohata, E, Inoue, T, Kaul, M, Parhi, A.K, LaVoie, E.J, Pilch, D.S, Matsumura, H. | 登録日 | 2017-03-30 | 公開日 | 2017-08-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ ACS Chem. Biol., 12, 2017
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5XDT
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![BU of 5xdt by Molmil](/molmil-images/mine/5xdt) | Staphylococcus aureus FtsZ 12-316 complexed with TXA707 | 分子名称: | 1-methylpyrrolidin-2-one, 2,6-bis(fluoranyl)-3-[[6-(trifluoromethyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]methoxy]benzamide, CALCIUM ION, ... | 著者 | Fujita, J, Maeda, Y, Mizohata, E, Inoue, T, Kaul, M, Parhi, A.K, LaVoie, E.J, Pilch, D.S, Matsumura, H. | 登録日 | 2017-03-30 | 公開日 | 2017-08-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ ACS Chem. Biol., 12, 2017
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5XAG
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![BU of 5xag by Molmil](/molmil-images/mine/5xag) | Crystal structure of tubulin-stathmin-TTL-Compound Z2 complex | 分子名称: | (3~{R},4~{R})-3-(hydroxymethyl)-4-(4-methoxy-3-oxidanyl-phenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Zhang, H, Luo, C, Wang, Y. | 登録日 | 2017-03-12 | 公開日 | 2018-01-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents Eur J Med Chem, 144, 2017
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5XAF
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![BU of 5xaf by Molmil](/molmil-images/mine/5xaf) | Crystal structure of tubulin-stathmin-TTL-Compound Z1 complex | 分子名称: | (3S,4R)-4-(3-hydroxy-4-methoxyphenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Zhang, H, Luo, C, Wang, Y. | 登録日 | 2017-03-12 | 公開日 | 2017-12-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.551 Å) | 主引用文献 | Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents Eur J Med Chem, 144, 2017
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5W3J
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![BU of 5w3j by Molmil](/molmil-images/mine/5w3j) | Yeast microtubule stabilized with Taxol assembled from mutated tubulin | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Howes, S.C, Geyer, E.A, LaFrance, B, Zhang, R, Kellogg, E.H, Westermann, S, Rice, L.M, Nogales, E. | 登録日 | 2017-06-07 | 公開日 | 2017-07-19 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural differences between yeast and mammalian microtubules revealed by cryo-EM. J. Cell Biol., 216, 2017
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5W3H
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![BU of 5w3h by Molmil](/molmil-images/mine/5w3h) | Yeast microtubule stabilized with epothilone | 分子名称: | EPOTHILONE A, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Howes, S.C, Geyer, E.A, LaFrance, B, Zhang, R, Kellogg, E.H, Westermann, S, Rice, L.M, Nogales, E. | 登録日 | 2017-06-07 | 公開日 | 2017-07-19 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural differences between yeast and mammalian microtubules revealed by cryo-EM. J. Cell Biol., 216, 2017
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5W3F
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![BU of 5w3f by Molmil](/molmil-images/mine/5w3f) | Yeast tubulin polymerized with GTP in vitro | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Howes, S.C, Geyer, E.A, LaFrance, B, Zhang, R, Kellogg, E.H, Westermann, S, Rice, L.M, Nogales, E. | 登録日 | 2017-06-07 | 公開日 | 2017-07-19 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural differences between yeast and mammalian microtubules revealed by cryo-EM. J. Cell Biol., 216, 2017
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5V68
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![BU of 5v68 by Molmil](/molmil-images/mine/5v68) | Crystal structure of cell division protein FtsZ from Mycobacterium tuberculosis bounded via the T9 loop | 分子名称: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION | 著者 | Lazo, E.O, Ojima, I, Chowdhury, S.R, Awasthi, D, Jakoncic, J. | 登録日 | 2017-03-16 | 公開日 | 2017-03-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.46 Å) | 主引用文献 | Novel T9 loop conformation of filamenting temperature-sensitive mutant Z from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.F, 75, 2019
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5UCY
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![BU of 5ucy by Molmil](/molmil-images/mine/5ucy) | Cryo-EM map of protofilament of microtubule doublet | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ichikawa, M, Liu, D, Kastritis, P.L, Basu, K, Bui, K.H. | 登録日 | 2016-12-22 | 公開日 | 2017-05-10 | 最終更新日 | 2020-01-15 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins. Nat Commun, 8, 2017
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5UBQ
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![BU of 5ubq by Molmil](/molmil-images/mine/5ubq) | Cryo-EM structure of ciliary microtubule doublet | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ichikawa, M, Liu, D, Kastritis, P.L, Basu, K, Bui, K.H. | 登録日 | 2016-12-21 | 公開日 | 2017-05-10 | 最終更新日 | 2020-01-15 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins. Nat Commun, 8, 2017
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5SYG
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![BU of 5syg by Molmil](/molmil-images/mine/5syg) | Cryo-EM reconstruction of zampanolide-bound microtubule | 分子名称: | (2Z,4E)-N-[(S)-[(1S,2E,5S,8E,10Z,17S)-3,11-dimethyl-19-methylidene-7,13-dioxo-6,21-dioxabicyclo[15.3.1]henicosa-2,8,10-trien-5-yl](hydroxy)methyl]hexa-2,4-dienamide, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Kellogg, E.H, Hejab, N.M.A, Nogales, E. | 登録日 | 2016-08-11 | 公開日 | 2017-02-01 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures. J. Mol. Biol., 429, 2017
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