5XAG

Crystal structure of tubulin-stathmin-TTL-Compound Z2 complex

Summary for 5XAG

Related5XAF
DescriptorTubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (14 entities in total)
Functional Keywordstubulin, structural protein
Biological sourceBos taurus (Bovine)
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Cellular locationCytoplasm, cytoskeleton P81947 Q6B856
Golgi apparatus  P63043
Total number of polymer chains6
Total molecular weight271049.74
Authors
Zhang, H.,Luo, C.,Wang, Y. (deposition date: 2017-03-12, release date: 2018-01-03, Last modification date: 2018-01-24)
Primary citation
Zhou, P.,Liang, Y.,Zhang, H.,Jiang, H.,Feng, K.,Xu, P.,Wang, J.,Wang, X.,Ding, K.,Luo, C.,Liu, M.,Wang, Y.
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144:817-842, 2017
PubMed: 29306206 (PDB entries with the same primary citation)
DOI: 10.1016/j.ejmech.2017.12.004
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.56 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25490.8%3.3%9.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution