5XP3
Crystal structure of apo T2R-TTL
Summary for 5XP3
Entry DOI | 10.2210/pdb5xp3/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | colchicine binding domain, tubulin inhibitor, tublin, structural protein |
Biological source | Sus scrofa (Pig) More |
Cellular location | Cytoplasm, cytoskeleton: Q2XVP4 F2Z5B2 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 264613.98 |
Authors | |
Primary citation | Jianhong, Y.,Wei, Y.,Yamei, Y.,Yuxi, W.,Tao, Y.,Linlin, X.,Xue, Y.,Caofeng, L.,Zuowei, L.,Xiaoxin, C.,Mengshi, H.,Li, Z.,Qiang, Q.,Heying, P.,Dan, L.,Fang, W.,Peng, B.,Jiaolin, W.,Haoyu, Y.,Lijuan, C. The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018 Cited by PubMed: 29691282DOI: 10.1074/jbc.RA117.001658 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report