5XLT
The crystal structure of tubulin in complex with 4'-demethylepipodophyllotoxin
Summary for 5XLT
Entry DOI | 10.2210/pdb5xlt/pdb |
Descriptor | Tubulin alpha-1B chain, (5S,5aR,8aR,9R)-9-(3,5-dimethoxy-4-oxidanyl-phenyl)-5-oxidanyl-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | tubulin, inhibitor, cell cycle |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265111.56 |
Authors | |
Primary citation | Niu, L.,Wang, Y.,Wang, C.,Wang, Y.,Jiang, X.,Ma, L.,Wu, C.,Yu, Y.,Chen, Q. Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design Biochem. Biophys. Res. Commun., 493:718-722, 2017 Cited by PubMed: 28864414DOI: 10.1016/j.bbrc.2017.08.125 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.813 Å) |
Structure validation
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