5XKE
Crystal structure of T2R-TTL-Demecolcine complex
Summary for 5XKE
Entry DOI | 10.2210/pdb5xke/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one, ... (12 entities in total) |
Functional Keywords | colchicine binding domain, tubulin inhibitor, tubulin, demecolcine, structural protein |
Biological source | Sus scrofa (Pig) More |
Total number of polymer chains | 6 |
Total formula weight | 264851.62 |
Authors | |
Primary citation | Yan, W.,Yang, J. Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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