5XKG

Crystal structure of T2R-TTL-CH1 complex

Summary for 5XKG

DescriptorTubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ... (12 entities in total)
Functional Keywordscolchicine binding domain, tubulin inhibitor, tublin, structural protein
Biological sourceSus scrofa (Pig)
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Cellular locationCytoplasm, cytoskeleton Q2XVP4 A0A287AGU7
Golgi apparatus  P63043
Total number of polymer chains6
Total molecular weight264701.41
Authors
Wang, Y.,Yang, J.,Wang, T.,Chen, L. (deposition date: 2017-05-07, release date: 2018-04-18)
Primary citation
Yan, W.,Yang, J.
Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24030.2%3.4%8.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution