5UBQ
| Cryo-EM structure of ciliary microtubule doublet | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ichikawa, M, Liu, D, Kastritis, P.L, Basu, K, Bui, K.H. | Deposit date: | 2016-12-21 | Release date: | 2017-05-10 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins. Nat Commun, 8, 2017
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5UCY
| Cryo-EM map of protofilament of microtubule doublet | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ichikawa, M, Liu, D, Kastritis, P.L, Basu, K, Bui, K.H. | Deposit date: | 2016-12-22 | Release date: | 2017-05-10 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins. Nat Commun, 8, 2017
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6U0T
| Protofilament Ribbon Flagellar Proteins Rib43a-S | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ichikawa, M, Khalifa, A.A.Z, Vargas, J, Basu, K, Bui, K.H. | Deposit date: | 2019-08-14 | Release date: | 2019-09-25 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.16 Å) | Cite: | Tubulin lattice in cilia is in a stressed form regulated by microtubule inner proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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6U0U
| Protofilament Ribbon Flagellar Proteins Rib43a-L | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ichikawa, M, Khalifa, A.A.Z, Vargas, J, Basu, K, Bui, K.H. | Deposit date: | 2019-08-14 | Release date: | 2019-09-25 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.16 Å) | Cite: | Tubulin lattice in cilia is in a stressed form regulated by microtubule inner proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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6U0H
| Tubulin lattice of the ciliary doublet microtubule from Tetrahymena thermophila | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ichikawa, M, Khalifa, A.A.Z, Vargas, J, Basu, K, Bui, K.H. | Deposit date: | 2019-08-14 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Tubulin lattice in cilia is in a stressed form regulated by microtubule inner proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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8J4C
| YeeE(TsuA)-YeeD(TsuB) complex for thiosulfate uptake | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Spirochaeta thermophila YeeE(TsuA)-YeeD(TsuB),UPF0033 domain-containing protein, SirA-like domain-containing protein (chimera), ... | Authors: | Ikei, M, Miyazaki, R, Monden, K, Naito, Y, Takeuchi, A, Takahashi, Y.S, Tanaka, Y, Ichikawa, M, Tsukazaki, T. | Deposit date: | 2023-04-19 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.34 Å) | Cite: | Structure and function of YeeE-YeeD complex for sophisticated thiosulfate uptake To Be Published
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7MOQ
| The structure of the Tetrahymena thermophila outer dynein arm on doublet microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Docking complex 1 protein, ... | Authors: | Kubo, S, Yang, S.K, Ichikawa, M, Bui, K.H. | Deposit date: | 2021-05-03 | Release date: | 2021-07-14 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-EM. Embo Rep., 22, 2021
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8K1R
| YeeE(TsuA)-YeeD(TsuB) complex for thiosulfate uptake | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Spirochaeta thermophila YeeE(TsuA)-YeeD(TsuB),UPF0033 domain-containing protein, SirA-like domain-containing protein (chimera) | Authors: | Ikei, M, Miyazaki, R, Monden, K, Naito, Y, Takeuchi, A, Takahashi, Y.S, Tanaka, Y, Ichikawa, M, Tsukazaki, T. | Deposit date: | 2023-07-11 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure and function of YeeE-YeeD complex for sophisticated thiosulfate uptake To Be Published
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4WVA
| Crystal structure of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8 in complex with Tris | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | Authors: | Miyazaki, T, Ichikawa, M, Nishikawa, A, Tonozuka, T. | Deposit date: | 2014-11-05 | Release date: | 2015-03-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Crystal structure and substrate-binding mode of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8. J.Struct.Biol., 190, 2015
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3W7X
| Crystal structure of E. coli YgjK D324N complexed with melibiose | Descriptor: | CALCIUM ION, Uncharacterized protein YgjK, alpha-D-galactopyranose-(1-6)-alpha-D-glucopyranose | Authors: | Miyazaki, T, Ichikawa, M, Yokoi, G, Kitaoka, M, Mori, H, Kitano, Y, Nishikawa, A, Tonozuka, T. | Deposit date: | 2013-03-08 | Release date: | 2013-07-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of a bacterial glycoside hydrolase family 63 enzyme in complex with its glycosynthase product, and insights into the substrate specificity. Febs J., 280, 2013
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4XPO
| Crystal structure of a novel alpha-galactosidase from Pedobacter saltans | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-glucosidase | Authors: | Miyazaki, T, Ishizaki, Y, Ichikawa, M, Nishikawa, A, Tonozuka, T. | Deposit date: | 2015-01-17 | Release date: | 2015-05-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31 Biochem.J., 469, 2015
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4XPR
| Crystal structure of the mutant D365A of Pedobacter saltans GH31 alpha-galactosidase | Descriptor: | 1,2-ETHANEDIOL, Alpha-glucosidase | Authors: | Miyazaki, T, Ishizaki, Y, Ichikawa, M, Nishikawa, A, Tonozuka, T. | Deposit date: | 2015-01-17 | Release date: | 2015-05-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31 Biochem.J., 469, 2015
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4XPP
| Crystal structure of Pedobacter saltans GH31 alpha-galactosidase complexed with D-galactose | Descriptor: | 1,2-ETHANEDIOL, Alpha-glucosidase, beta-D-galactopyranose | Authors: | Miyazaki, T, Ishizaki, Y, Ichikawa, M, Nishikawa, A, Tonozuka, T. | Deposit date: | 2015-01-17 | Release date: | 2015-05-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31 Biochem.J., 469, 2015
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4XPQ
| Crystal structure of Pedobacter saltans GH31 alpha-galactosidase complexed with L-fucose | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-glucosidase, ... | Authors: | Miyazaki, T, Ishizaki, Y, Ichikawa, M, Nishikawa, A, Tonozuka, T. | Deposit date: | 2015-01-17 | Release date: | 2015-05-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31 Biochem.J., 469, 2015
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4XPS
| Crystal structure of the mutant D365A of Pedobacter saltans GH31 alpha-galactosidase complexed with p-nitrophenyl-alpha-galactopyranoside | Descriptor: | 1,2-ETHANEDIOL, Alpha-glucosidase, P-NITROPHENOL, ... | Authors: | Miyazaki, T, Ishizaki, Y, Ichikawa, M, Nishikawa, A, Tonozuka, T. | Deposit date: | 2015-01-17 | Release date: | 2015-05-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31 Biochem.J., 469, 2015
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3Q2Z
| Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid | Descriptor: | N-{[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl}-L-aspartic acid, PHOSPHATE ION, Squalene synthase | Authors: | Suzuki, M, Shimizu, H, Katakura, S, Yamazaki, K, Higashihashi, N, Ichikawa, M, Yokomizo, A, Itoh, M, Sugita, K, Usui, H. | Deposit date: | 2010-12-21 | Release date: | 2011-12-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors Bioorg.Med.Chem., 19, 2011
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3Q30
| Human Squalene synthase in complex with (2R,3R)-2-Carboxymethoxy-3-[5-(2-naphthalenyl)pentyl]aminocarbonyl-3-[5-(2-naphthalenyl)pentyloxy]propionic acid | Descriptor: | (2R,3R)-2-(carboxymethoxy)-4-{[5-(naphthalen-2-yl)pentyl]amino}-3-{[5-(naphthalen-2-yl)pentyl]oxy}-4-oxobutanoic acid, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Suzuki, M, Shimizu, H, Katakura, S, Yamazaki, K, Higashihashi, N, Ichikawa, M, Yokomizo, A, Itoh, M, Sugita, K, Usui, H. | Deposit date: | 2010-12-21 | Release date: | 2011-12-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors Bioorg.Med.Chem., 19, 2011
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4WVC
| Crystal structure of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8 in complex with Tris and D-glycerate | Descriptor: | (2R)-2,3-DIHYDROXYPROPANOIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | Authors: | Miyazaki, T, Ichikawa, M, Nishikawa, A, Tonozuka, T. | Deposit date: | 2014-11-05 | Release date: | 2015-03-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure and substrate-binding mode of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8. J.Struct.Biol., 190, 2015
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4WVB
| Crystal structure of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8 in complex with glucose | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Uncharacterized protein, ... | Authors: | Miyazaki, T, Ichikawa, M, Nishikawa, A, Tonozuka, T. | Deposit date: | 2014-11-05 | Release date: | 2015-03-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal structure and substrate-binding mode of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8. J.Struct.Biol., 190, 2015
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6VE7
| The inner junction complex of Chlamydomonas reinhardtii doublet microtubule | Descriptor: | Cilia- and flagella-associated protein 20, FAP276, FAP52, ... | Authors: | Khalifa, A.A.Z, Ichikawa, M, Bui, K.H. | Deposit date: | 2019-12-30 | Release date: | 2020-02-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications. Elife, 9, 2020
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3V66
| HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid | Descriptor: | (1-{[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}piperidin-4-yl)acetic acid, PHOSPHATE ION, Squalene synthase | Authors: | Suzuki, M, Ohtsuka, M, Ohki, H, Haginoya, N, Itoh, M, Sugita, K, Usui, H, Ichikawa, M, Higashihashi, N. | Deposit date: | 2011-12-18 | Release date: | 2012-12-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of novel tricyclic compounds as squalene synthase inhibitors Bioorg.Med.Chem., 20, 2012
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3W7W
| Crystal structure of E. coli YgjK E727A complexed with 2-O-alpha-D-glucopyranosyl-alpha-D-galactopyranose | Descriptor: | CALCIUM ION, MAGNESIUM ION, Uncharacterized protein YgjK, ... | Authors: | Miyazaki, T, Ichikawa, M, Yokoi, G, Kitaoka, M, Mori, H, Kitano, Y, Nishikawa, A, Tonozuka, T. | Deposit date: | 2013-03-08 | Release date: | 2013-07-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of a bacterial glycoside hydrolase family 63 enzyme in complex with its glycosynthase product, and insights into the substrate specificity. Febs J., 280, 2013
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3VSR
| Microbacterium saccharophilum K-1 beta-fructofuranosidase catalytic domain | Descriptor: | Beta-fructofuranosidase | Authors: | Tonozuka, T, Tamaki, A, Yokoi, G, Miyazaki, T, Ichikawa, M, Nishikawa, A, Ohta, Y, Hidaka, Y, Katayama, K, Hatada, Y, Ito, T, Fujita, K. | Deposit date: | 2012-05-08 | Release date: | 2012-08-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a lactosucrose-producing enzyme, Arthrobacter sp. K-1 beta-fructofuranosidase Enzyme.Microb.Technol., 51, 2012
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3VSS
| Microbacterium saccharophilum K-1 beta-fructofuranosidase catalytic domain complexed with fructose | Descriptor: | Beta-fructofuranosidase, beta-D-fructofuranose | Authors: | Tonozuka, T, Tamaki, A, Yokoi, G, Miyazaki, T, Ichikawa, M, Nishikawa, A, Ohta, Y, Hidaka, Y, Katayama, K, Hatada, Y, Ito, T, Fujita, K. | Deposit date: | 2012-05-08 | Release date: | 2012-08-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Crystal structure of a lactosucrose-producing enzyme, Arthrobacter sp. K-1 beta-fructofuranosidase Enzyme.Microb.Technol., 51, 2012
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3ASX
| Human Squalene synthase in complex with 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid | Descriptor: | (3R)-1-{4-[{4-chloro-2-[(S)-(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid, PHOSPHATE ION, Squalene synthase | Authors: | Shimizu, H, Suzuki, M, Katakura, S, Yamazaki, K, Higashihashi, N, Ichikawa, M, Yokomizo, A, Itoh, M, Sugita, K, Usui, H. | Deposit date: | 2010-12-22 | Release date: | 2011-12-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors Bioorg.Med.Chem., 19, 2011
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