6CKV
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![BU of 6ckv by Molmil](/molmil-images/mine/6ckv) | |
7XGE
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![BU of 7xge by Molmil](/molmil-images/mine/7xge) | |
3WIY
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![BU of 3wiy by Molmil](/molmil-images/mine/3wiy) | Crystal structure of Mcl-1 in complex with compound 10 | 分子名称: | 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Sogabe, S, Igaki, S, Hayano, Y. | 登録日 | 2013-09-26 | 公開日 | 2013-11-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins. J.Med.Chem., 56, 2013
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3WIX
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![BU of 3wix by Molmil](/molmil-images/mine/3wix) | Crystal structure of Mcl-1 in complex with compound 4 | 分子名称: | 7-(4-carboxyphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Sogabe, S, Igaki, S, Hayano, Y. | 登録日 | 2013-09-26 | 公開日 | 2013-11-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins. J.Med.Chem., 56, 2013
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2ROC
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![BU of 2roc by Molmil](/molmil-images/mine/2roc) | Solution structure of Mcl-1 Complexed with Puma | 分子名称: | Bcl-2-binding component 3, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog | 著者 | Day, C.L, Smits, C, Fan, F.C, Lee, E.F, Fairlie, W.D, Hinds, M.G. | 登録日 | 2008-03-17 | 公開日 | 2008-07-08 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1 J.Mol.Biol., 380, 2008
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8SM5
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![BU of 8sm5 by Molmil](/molmil-images/mine/8sm5) | |
8SRY
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![BU of 8sry by Molmil](/molmil-images/mine/8sry) | Crystal structure of BAK-BAX heterodimer with C12E8 | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, ... | 著者 | Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S. | 登録日 | 2023-05-08 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
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8SRX
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![BU of 8srx by Molmil](/molmil-images/mine/8srx) | Crystal structure of BAK-BAX heterodimer with lysoPC | 分子名称: | 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2 homologous antagonist/killer, ... | 著者 | Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S. | 登録日 | 2023-05-07 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
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8SPZ
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![BU of 8spz by Molmil](/molmil-images/mine/8spz) | |
8SPF
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![BU of 8spf by Molmil](/molmil-images/mine/8spf) | Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with 2-stearoyl lysoPC | 分子名称: | 1,2-ETHANEDIOL, Apoptosis regulator BAX, DODECANE, ... | 著者 | Cowan, A.D, Miller, M.S, Czabotar, P.E, Colman, P.M. | 登録日 | 2023-05-03 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
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8SVK
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![BU of 8svk by Molmil](/molmil-images/mine/8svk) | |
8SPE
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![BU of 8spe by Molmil](/molmil-images/mine/8spe) | Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P31 | 分子名称: | 1,2-ETHANEDIOL, Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, ... | 著者 | Miller, M.S, Cowan, A.D, Colman, P.M, Czabotar, P.E. | 登録日 | 2023-05-03 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023
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2VOG
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![BU of 2vog by Molmil](/molmil-images/mine/2vog) | Structure of mouse A1 bound to the Bmf BH3-domain | 分子名称: | BCL-2-MODIFYING FACTOR, BCL-2-RELATED PROTEIN A1, CHLORIDE ION | 著者 | Smits, C, Czabotar, P.E, Hinds, M.G, Day, C.L. | 登録日 | 2008-02-17 | 公開日 | 2008-03-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1. Structure, 16, 2008
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2VOI
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![BU of 2voi by Molmil](/molmil-images/mine/2voi) | Structure of mouse A1 bound to the Bid BH3-domain | 分子名称: | BCL-2-RELATED PROTEIN A1, BH3-INTERACTING DOMAIN DEATH AGONIST P13, CHLORIDE ION | 著者 | Smits, C, Czabotar, P.E, Hinds, M.G, Day, C.L. | 登録日 | 2008-02-17 | 公開日 | 2008-03-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1. Structure, 16, 2008
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2VOH
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![BU of 2voh by Molmil](/molmil-images/mine/2voh) | Structure of mouse A1 bound to the Bak BH3-domain | 分子名称: | BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, BCL-2-RELATED PROTEIN A1, CITRIC ACID, ... | 著者 | Smits, C, Czabotar, P.E, Hinds, M.G, Day, C.L. | 登録日 | 2008-02-17 | 公開日 | 2008-03-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1. Structure, 16, 2008
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8UKY
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![BU of 8uky by Molmil](/molmil-images/mine/8uky) | |
2VOF
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![BU of 2vof by Molmil](/molmil-images/mine/2vof) | Structure of mouse A1 bound to the Puma BH3-domain | 分子名称: | BCL-2-BINDING COMPONENT 3, BCL-2-RELATED PROTEIN A1, CHLORIDE ION | 著者 | Smits, C, Czabotar, P.E, Hinds, M.G, Day, C.L. | 登録日 | 2008-02-17 | 公開日 | 2008-03-04 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1. Structure, 16, 2008
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6MBE
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![BU of 6mbe by Molmil](/molmil-images/mine/6mbe) | Human Mcl-1 in complex with the designed peptide dM7 | 分子名称: | CHLORIDE ION, Induced myeloid leukemia cell differentiation protein Mcl-1, dM7 | 著者 | Jenson, J.M, Keating, A.E. | 登録日 | 2018-08-29 | 公開日 | 2019-03-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure, 27, 2019
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6MCY
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![BU of 6mcy by Molmil](/molmil-images/mine/6mcy) | Crystal structure of mouse Bak | 分子名称: | 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, FORMIC ACID | 著者 | Brouwer, J.M, Czabotar, P.E, Colman, P.M. | 登録日 | 2018-09-03 | 公開日 | 2019-09-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.748 Å) | 主引用文献 | A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nat.Chem.Biol., 15, 2019
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6MBD
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![BU of 6mbd by Molmil](/molmil-images/mine/6mbd) | Human Mcl-1 in complex with the designed peptide dM1 | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, dM1 | 著者 | Jenson, J.M, Keating, A.E. | 登録日 | 2018-08-29 | 公開日 | 2019-03-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure, 27, 2019
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6MBC
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![BU of 6mbc by Molmil](/molmil-images/mine/6mbc) | |
6NE5
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![BU of 6ne5 by Molmil](/molmil-images/mine/6ne5) | |
6O6F
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![BU of 6o6f by Molmil](/molmil-images/mine/6o6f) | Co-crystal structure of Mcl1 with inhibitor | 分子名称: | (3S)-5'-chloro-5-(cyclobutylmethyl)-2',3',4,5-tetrahydro-2H-spiro[1,5-benzoxazepine-3,1'-indene]-7-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Huang, X. | 登録日 | 2019-03-06 | 公開日 | 2019-05-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies. Cancer Discov, 8, 2018
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6ODH
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![BU of 6odh by Molmil](/molmil-images/mine/6odh) | BH3 domain swapped dimer of a BAK fragment | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bcl-2 homologous antagonist/killer, DI(HYDROXYETHYL)ETHER, ... | 著者 | Liu, L.-K. | 登録日 | 2019-03-26 | 公開日 | 2020-10-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A BAK fragment that binds mitochondrial lipids and releases cytochrome c To Be Published
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6O4U
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![BU of 6o4u by Molmil](/molmil-images/mine/6o4u) | Co-crystal structure of Mcl1 with inhibitor | 分子名称: | (2~{S})-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-~{N}-(2-methylpropylsulfonyl)-2,3-dihydro-1,4-benzoxazine-6-carboxamide, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Huang, X. | 登録日 | 2019-03-01 | 公開日 | 2020-03-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Conformational Restriction Toward the Discovery of Macrocyclic MCL1 Inhibitors that Display Efficacy in Mouse Xenograft Models To Be Published
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