8SPF

Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with 2-stearoyl lysoPC

Summary for 8SPF

Entry DOI	10.2210/pdb8spf/pdb
Descriptor	Apoptosis regulator BAX, SN-GLYCEROL-1-PHOSPHATE, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	bax, bcl2, apoptosis
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	54728.60
Authors	Cowan, A.D.,Miller, M.S.,Czabotar, P.E.,Colman, P.M. (deposition date: 2023-05-03, release date: 2023-12-27)
Primary citation	Miller, M.S.,Cowan, A.D.,Brouwer, J.M.,Smyth, S.T.,Peng, L.,Wardak, A.Z.,Uren, R.T.,Luo, C.,Roy, M.J.,Shah, S.,Tan, Z.,Reid, G.E.,Colman, P.M.,Czabotar, P.E. Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023 Cited by PubMed: 38088212 DOI: 10.1111/febs.17031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation