8SPE

Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P31

Summary for 8SPE

Entry DOI	10.2210/pdb8spe/pdb
Descriptor	Apoptosis regulator BAX, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	bax, bcl2, apoptosis
Biological source	Homo sapiens (human)
Total number of polymer chains	36
Total formula weight	324067.42
Authors	Miller, M.S.,Cowan, A.D.,Colman, P.M.,Czabotar, P.E. (deposition date: 2023-05-03, release date: 2023-12-27)
Primary citation	Miller, M.S.,Cowan, A.D.,Brouwer, J.M.,Smyth, S.T.,Peng, L.,Wardak, A.Z.,Uren, R.T.,Luo, C.,Roy, M.J.,Shah, S.,Tan, Z.,Reid, G.E.,Colman, P.M.,Czabotar, P.E. Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 2023 Cited by PubMed: 38088212 DOI: 10.1111/febs.17031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation