6MBE

Human Mcl-1 in complex with the designed peptide dM7

Summary for 6MBE

Entry DOI	10.2210/pdb6mbe/pdb
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, dM7, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	anti-apoptotic bcl-2, inhibitor, design, apoptosis
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	20227.50
Authors	Jenson, J.M.,Keating, A.E. (deposition date: 2018-08-29, release date: 2019-03-06, Last modification date: 2023-10-11)
Primary citation	Frappier, V.,Jenson, J.M.,Zhou, J.,Grigoryan, G.,Keating, A.E. Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure, 27:606-617.e5, 2019 Cited by PubMed: 30773399 DOI: 10.1016/j.str.2019.01.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation