8SRY

Crystal structure of BAK-BAX heterodimer with C12E8

Summary for 8SRY

• Entry DOI: 10.2210/pdb8sry/pdb
• Descriptor: Bcl-2 homologous antagonist/killer, Apoptosis regulator BAX, 2-(2-METHOXYETHOXY)ETHANOL, ... (8 entities in total)
• Functional Keywords: bax, bak, bcl2, apoptosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 38507.34

Authors

Brouwer, J.M.,Czabotar, P.E.,Colman, P.M.,Miller, M.S. (deposition date: 2023-05-08, release date: 2023-12-27, Last modification date: 2024-06-19)

• Primary citation: Miller, M.S.,Cowan, A.D.,Brouwer, J.M.,Smyth, S.T.,Peng, L.,Wardak, A.Z.,Uren, R.T.,Luo, C.,Roy, M.J.,Shah, S.,Tan, Z.,Reid, G.E.,Colman, P.M.,Czabotar, P.E.; Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.; Febs J., 291:2335-2353, 2024; PubMed: 38088212; DOI: 10.1111/febs.17031

Experimental method

X-RAY DIFFRACTION (2.4 Å)