8SRY

Crystal structure of BAK-BAX heterodimer with C12E8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Bcl-2 homologous antagonist/killer	polymer	91	9832.9	2	UniProt (Q16611) Pfam (PF00452)	Homo sapiens (human)	Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7
2	B, D (B, D)	Apoptosis regulator BAX	polymer	80	8819.0	2	UniProt (Q07812) Pfam (PF00452)	Homo sapiens (human)	Bcl-2-like protein 4,Bcl2-L-4
3	E (A)	2-(2-METHOXYETHOXY)ETHANOL	non-polymer		120.1	1	Chemie (PG0)
4	F, I (B, D)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5	G (B)	3,6,9,12,15-PENTAOXATRICOSAN-1-OL	non-polymer		350.5	1	Chemie (N8E)
6	H (C)	3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL	non-polymer		326.4	1	Chemie (P33)
7	J (D)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
8	K (A)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

A, C: 68 - 146 (UniProt: Q16611)

PDB	External Database	Details
Gly 64	-	expression tag
Pro 65	-	expression tag
Leu 66	-	expression tag
Gly 67	-	expression tag
Gly 147	-	expression tag
Ser 148	-	expression tag
Gly 149	-	expression tag
Gly 150	-	expression tag
Ser 151	-	expression tag
Gly 152	-	expression tag
Gly 153	-	expression tag
Ser 154	-	expression tag

B, D: 53 - 128 (UniProt: Q07812)

PDB	External Database	Details
Gly 49	-	expression tag
Gly 50	-	expression tag
Ser 51	-	expression tag
Gly 52	-	expression tag
Ser 62	Cys 62	conflict
Ser 126	Cys 126	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	37303.8
Non-Polymers*	Number of molecules	6
	Total formula weight	1203.5
All*	Total formula weight	38507.3

*Water molecules are not included.