6MCY

Crystal structure of mouse Bak

Summary for 6MCY

• Entry DOI: 10.2210/pdb6mcy/pdb
• Descriptor: Bcl-2 homologous antagonist/killer, FORMIC ACID, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bcl-2 family, bak, alpha-helical, apoptosis
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 4
• Total formula weight: 76257.22

Authors

Brouwer, J.M.,Czabotar, P.E.,Colman, P.M. (deposition date: 2018-09-03, release date: 2019-09-11, Last modification date: 2023-10-11)

• Primary citation: van Delft, M.F.,Chappaz, S.,Khakham, Y.,Bui, C.T.,Debrincat, M.A.,Lowes, K.N.,Brouwer, J.M.,Grohmann, C.,Sharp, P.P.,Dagley, L.F.,Li, L.,McArthur, K.,Luo, M.X.,Chin, H.S.,Fairlie, W.D.,Lee, E.F.,Segal, D.,Duflocq, S.,Lessene, R.,Bernard, S.,Peilleron, L.,Nguyen, T.,Miles, C.,Wan, S.S.,Lane, R.M.,Wardak, A.,Lackovic, K.,Colman, P.M.,Sandow, J.J.,Webb, A.I.,Czabotar, P.E.,Dewson, G.,Watson, K.G.,Huang, D.C.S.,Lessene, G.,Kile, B.T.; A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.; Nat.Chem.Biol., 15:1057-1066, 2019; PubMed: 31591564; DOI: 10.1038/s41589-019-0365-8

Experimental method

X-RAY DIFFRACTION (1.748 Å)