6O6F

Co-crystal structure of Mcl1 with inhibitor

Summary for 6O6F

• Entry DOI: 10.2210/pdb6o6f/pdb
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, (3S)-5'-chloro-5-(cyclobutylmethyl)-2',3',4,5-tetrahydro-2H-spiro[1,5-benzoxazepine-3,1'-indene]-7-carboxylic acid (3 entities in total)
• Functional Keywords: apoptosis, inhibition, apoptosis-inhibitor complex, apoptosis/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 36670.51

Authors

Huang, X. (deposition date: 2019-03-06, release date: 2019-05-15, Last modification date: 2024-03-13)

• Primary citation: Caenepeel, S.,Brown, S.P.,Belmontes, B.,Moody, G.,Keegan, K.S.,Chui, D.,Whittington, D.A.,Huang, X.,Poppe, L.,Cheng, A.C.,Cardozo, M.,Houze, J.,Li, Y.,Lucas, B.,Paras, N.A.,Wang, X.,Taygerly, J.P.,Vimolratana, M.,Zancanella, M.,Zhu, L.,Cajulis, E.,Osgood, T.,Sun, J.,Damon, L.,Egan, R.K.,Greninger, P.,McClanaghan, J.D.,Gong, J.,Moujalled, D.,Pomilio, G.,Beltran, P.,Benes, C.H.,Roberts, A.W.,Huang, D.C.,Wei, A.,Canon, J.,Coxon, A.,Hughes, P.E.; AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.; Cancer Discov, 8:1582-1597, 2018; PubMed: 30254093; DOI: 10.1158/2159-8290.CD-18-0387

Experimental method

X-RAY DIFFRACTION (1.6 Å)