8SRX

Crystal structure of BAK-BAX heterodimer with lysoPC

Summary for 8SRX

Entry DOI	10.2210/pdb8srx/pdb
Descriptor	Bcl-2 homologous antagonist/killer, Apoptosis regulator BAX, [(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate, ... (9 entities in total)
Functional Keywords	bax, bak, bcl2, apoptosis
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	39276.98
Authors	Brouwer, J.M.,Czabotar, P.E.,Colman, P.M.,Miller, M.S. (deposition date: 2023-05-07, release date: 2023-12-27, Last modification date: 2024-06-19)
Primary citation	Miller, M.S.,Cowan, A.D.,Brouwer, J.M.,Smyth, S.T.,Peng, L.,Wardak, A.Z.,Uren, R.T.,Luo, C.,Roy, M.J.,Shah, S.,Tan, Z.,Reid, G.E.,Colman, P.M.,Czabotar, P.E. Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 291:2335-2353, 2024 Cited by PubMed: 38088212 DOI: 10.1111/febs.17031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation