8SRX

Crystal structure of BAK-BAX heterodimer with lysoPC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Bcl-2 homologous antagonist/killer	polymer	91	9832.9	2	UniProt (Q16611) Pfam (PF00452)	Homo sapiens (human)	Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7
2	B, D (B, D)	Apoptosis regulator BAX	polymer	80	8819.0	2	UniProt (Q07812) Pfam (PF00452)	Homo sapiens (human)	Bcl-2-like protein 4,Bcl2-L-4
3	E, H, K (A, B, D)	[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate	non-polymer		496.6	3	Chemie (K6G)
4	F (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	G, J (A, B)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6	I, L (B, D)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
7	M, N (D)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
8	O (D)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
9	P, Q, R, S (A, B, C, D)	water	water		18.0	114	Chemie (HOH)

Sequence modifications

A, C: 68 - 146 (UniProt: Q16611)

PDB	External Database	Details
Gly 64	-	expression tag
Pro 65	-	expression tag
Leu 66	-	expression tag
Gly 67	-	expression tag
Gly 147	-	expression tag
Ser 148	-	expression tag
Gly 149	-	expression tag
Gly 150	-	expression tag
Ser 151	-	expression tag
Gly 152	-	expression tag
Gly 153	-	expression tag
Ser 154	-	expression tag

B, D: 53 - 128 (UniProt: Q07812)

PDB	External Database	Details
Gly 49	-	expression tag
Gly 50	-	expression tag
Ser 51	-	expression tag
Gly 52	-	expression tag
Ser 62	Cys 62	conflict
Ser 126	Cys 126	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	37303.8
Non-Polymers*	Number of molecules	11
	Total formula weight	1973.1
All*	Total formula weight	39277.0

*Water molecules are not included.