3CWW
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![BU of 3cww by Molmil](/molmil-images/mine/3cww) | Crystal Structure of IDE-bradykinin complex | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ACETATE ION, Insulin-degrading enzyme, ... | 著者 | Malito, E, Tang, W.J. | 登録日 | 2008-04-23 | 公開日 | 2008-11-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme Biochemistry, 47, 2008
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2G47
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![BU of 2g47 by Molmil](/molmil-images/mine/2g47) | |
2G56
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4PFC
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![BU of 4pfc by Molmil](/molmil-images/mine/4pfc) | Crystal structure of insulin degrading enzyme complexed with inhibitor | 分子名称: | Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate | 著者 | Wang, Y, Guo, S. | 登録日 | 2014-04-28 | 公開日 | 2015-06-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290, 2015
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4PES
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![BU of 4pes by Molmil](/molmil-images/mine/4pes) | |
2G54
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3E4Z
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![BU of 3e4z by Molmil](/molmil-images/mine/3e4z) | Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II | 分子名称: | Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION | 著者 | Guo, Q, Manolopoulou, M, Tang, W.-J. | 登録日 | 2008-08-12 | 公開日 | 2009-08-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
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3E50
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![BU of 3e50 by Molmil](/molmil-images/mine/3e50) | Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha | 分子名称: | Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION | 著者 | Guo, Q, Manolopoulou, M, Tang, W.-J. | 登録日 | 2008-08-12 | 公開日 | 2009-08-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
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4PF7
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![BU of 4pf7 by Molmil](/molmil-images/mine/4pf7) | Crystal structure of insulin degrading enzyme complexed with inhibitor | 分子名称: | (2S)-2-amino-N-{(1S)-1-cyclohexyl-2-[(4-methylphenyl)amino]-2-oxoethyl}-4-(methylselanyl)butanamide, Insulin-degrading enzyme, ZINC ION | 著者 | Wang, Y, Guo, S. | 登録日 | 2014-04-28 | 公開日 | 2015-06-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290, 2015
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3OFI
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![BU of 3ofi by Molmil](/molmil-images/mine/3ofi) | Crystal structure of human insulin-degrading enzyme in complex with ubiquitin | 分子名称: | 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, Ubiquitin, ... | 著者 | Kalas, V, Ralat, L.A, Tang, W.-J. | 登録日 | 2010-08-15 | 公開日 | 2010-09-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Ubiquitin is a novel substrate for human insulin-degrading enzyme. J.Mol.Biol., 406, 2011
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2G49
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4PF9
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![BU of 4pf9 by Molmil](/molmil-images/mine/4pf9) | Crystal structure of insulin degrading enzyme complexed with inhibitor | 分子名称: | Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate | 著者 | Wang, Y, Guo, S. | 登録日 | 2014-04-28 | 公開日 | 2015-06-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290, 2015
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2WK3
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2G48
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7K1F
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![BU of 7k1f by Molmil](/molmil-images/mine/7k1f) | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88558 | 分子名称: | 1,4-DIETHYLENE DIOXIDE, 3,4-difluoro-N-({1-[(2R)-4-(hydroxyamino)-4-oxo-1-(quinolin-7-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Bosc, D, Tang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 4 To Be Published
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2WBY
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![BU of 2wby by Molmil](/molmil-images/mine/2wby) | Crystal structure of human insulin-degrading enzyme in complex with insulin | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN, INSULIN-DEGRADING ENZYME, ... | 著者 | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | 登録日 | 2009-03-06 | 公開日 | 2009-03-24 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme. J.Biol.Chem., 284, 2009
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3E4A
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![BU of 3e4a by Molmil](/molmil-images/mine/3e4a) | Human IDE-inhibitor complex at 2.6 angstrom resolution | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ACETIC ACID, HYDROXAMATE PEPTIDE II1, ... | 著者 | Malito, E, Leissring, M.A, Choi, S, Cuny, G.D, Tang, W.J. | 登録日 | 2008-08-11 | 公開日 | 2009-05-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One, 5, 2010
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4GSF
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![BU of 4gsf by Molmil](/molmil-images/mine/4gsf) | The structure analysis of cysteine free insulin degrading enzyme (ide) with (s)-2-{2-[carboxymethyl-(3-phenyl-propionyl)-amino]-acetylamino}-3-(3h-imidazol-4-yl)-propionic acid methyl ester | 分子名称: | Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate | 著者 | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | 登録日 | 2012-08-27 | 公開日 | 2013-08-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur.J.Med.Chem., 90, 2015
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4LTE
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![BU of 4lte by Molmil](/molmil-images/mine/4lte) | Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor | 分子名称: | 2,6-DIAMINO-HEXANOIC ACID AMIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FUMARIC ACID, ... | 著者 | Foda, Z.H, Seeliger, M.A, Saghatelian, A, Liu, D.R. | 登録日 | 2013-07-23 | 公開日 | 2014-05-21 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.705 Å) | 主引用文献 | Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature, 511, 2014
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4NXO
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![BU of 4nxo by Molmil](/molmil-images/mine/4nxo) | Crystal Structure of Insulin Degrading Enzyme in complex with BDM44768 | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Deprez, B, Tang, W. | 登録日 | 2013-12-09 | 公開日 | 2015-10-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun, 6, 2015
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2YPU
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![BU of 2ypu by Molmil](/molmil-images/mine/2ypu) | human insulin degrading enzyme E111Q in complex with inhibitor compound 41367 | 分子名称: | 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, INSULIN-DEGRADING ENZYME, ZINC ION | 著者 | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.-J. | 登録日 | 2012-11-01 | 公開日 | 2012-11-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Imidazole-Derived 2-[N-Carbamoylmethyl-Alkylamino]Acetic Acids,Substrate-Dependent Modulators of Insulin-Degrading Enzyme in Amyloid-Beta Hydrolysis Eur J Med Chem, 79C, 2014
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2JG4
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![BU of 2jg4 by Molmil](/molmil-images/mine/2jg4) | Substrate-free IDE structure in its closed conformation | 分子名称: | 1,4-DIETHYLENE DIOXIDE, INSULIN DEGRADING ENZYME, ZINC ION | 著者 | Malito, E, Tang, W.J. | 登録日 | 2007-02-07 | 公開日 | 2007-07-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282, 2007
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7K1E
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![BU of 7k1e by Molmil](/molmil-images/mine/7k1e) | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646 | 分子名称: | 1,4-DIETHYLENE DIOXIDE, 3,4-difluoro-N-[(1S)-1-{1-[(2R)-4-(hydroxyamino)-4-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}ethyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Bosc, D, Tang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 3 To Be Published
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2WC0
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![BU of 2wc0 by Molmil](/molmil-images/mine/2wc0) | crystal structure of human insulin degrading enzyme in complex with iodinated insulin | 分子名称: | 1,4-DIETHYLENE DIOXIDE, INSULIN A CHAIN, INSULIN B CHAIN, ... | 著者 | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | 登録日 | 2009-03-06 | 公開日 | 2009-03-24 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme. J.Biol.Chem., 284, 2009
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4GSC
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![BU of 4gsc by Molmil](/molmil-images/mine/4gsc) | Structure analysis of insulin degrading enzyme with compound bdm41559 ((s)-2-[2-(carboxymethyl-phenethyl-amino)-acetylamino]-3-(1h-imidazol-4-yl)-propionic acid methyl ester) | 分子名称: | Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(2-phenylethyl)glycyl-L-histidinate | 著者 | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | 登録日 | 2012-08-27 | 公開日 | 2013-08-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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