4PES
Crystal structure of insulin degrading enzyme complexed with inhibitor tert-butyl [(2S)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl)propyl]carbamate
Summary for 4PES
Entry DOI | 10.2210/pdb4pes/pdb |
Descriptor | Insulin-degrading enzyme, Ala-Ala-Ala, tert-butyl [(2S)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl)propyl]carbamate, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: P14735 |
Total number of polymer chains | 4 |
Total formula weight | 230377.18 |
Authors | |
Primary citation | Durham, T.B.,Toth, J.L.,Klimkowski, V.J.,Cao, J.X.C.,Siesky, A.M.,Alexander-Chacko, J.,Wu, G.Y.,Dixon, J.T.,McGee, J.E.,Wang, Y.,Guo, S.,Cavitt, R.N.,Schindler, J.,Thibodeaux, S.J.,Calvert, N.A.,Coghlan, M.J.,Sindelar, D.K.,Christe, M.,Kiselyov, V.V.,Dodson, M.,Sloop, K.W. Crystal structure of IDE complexed with an inhibitor To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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