4GSF

The structure analysis of cysteine free insulin degrading enzyme (ide) with (s)-2-{2-[carboxymethyl-(3-phenyl-propionyl)-amino]-acetylamino}-3-(3h-imidazol-4-yl)-propionic acid methyl ester

Summary for 4GSF

• Entry DOI: 10.2210/pdb4gsf/pdb
• Related: 4GS8 4GSC 4GSE
• Descriptor: Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate, ZINC ION, ... (4 entities in total)
• Functional Keywords: insulin degrading enzyme, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14735
• Total number of polymer chains: 2
• Total formula weight: 230084.83

Authors

Guo, Q.,Deprez-Poulain, R.,Deprez, B.,Tang, W.J. (deposition date: 2012-08-27, release date: 2013-08-28, Last modification date: 2023-09-13)

• Primary citation: Charton, J.,Gauriot, M.,Totobenazara, J.,Hennuyer, N.,Dumont, J.,Bosc, D.,Marechal, X.,Elbakali, J.,Herledan, A.,Wen, X.,Ronco, C.,Gras-Masse, H.,Heninot, A.,Pottiez, V.,Landry, V.,Staels, B.,Liang, W.G.,Leroux, F.,Tang, W.J.,Deprez, B.,Deprez-Poulain, R.; Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.; Eur.J.Med.Chem., 90:547-567, 2015; PubMed: 25489670; DOI: 10.1016/j.ejmech.2014.12.005

Experimental method

X-RAY DIFFRACTION (2.7 Å)