4PF9
Crystal structure of insulin degrading enzyme complexed with inhibitor
Summary for 4PF9
Entry DOI | 10.2210/pdb4pf9/pdb |
Related | 4PES 4PF7 |
Descriptor | Insulin-degrading enzyme, methyl [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate, ZINC ION, ... (4 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P14735 |
Total number of polymer chains | 2 |
Total formula weight | 230585.66 |
Authors | |
Primary citation | Durham, T.B.,Toth, J.L.,Klimkowski, V.J.,Cao, J.X.,Siesky, A.M.,Alexander-Chacko, J.,Wu, G.Y.,Dixon, J.T.,McGee, J.E.,Wang, Y.,Guo, S.Y.,Cavitt, R.N.,Schindler, J.,Thibodeaux, S.J.,Calvert, N.A.,Coghlan, M.J.,Sindelar, D.K.,Christe, M.,Kiselyov, V.V.,Michael, M.D.,Sloop, K.W. Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290:20044-20059, 2015 Cited by PubMed: 26085101DOI: 10.1074/jbc.M115.638205 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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