Crystal structure of human insulin-degrading enzyme in complex with ubiquitin

Summary for 3OFI

DescriptorInsulin-degrading enzyme, Ubiquitin, ZINC ION, ... (5 entities in total)
Functional Keywordsprotein-peptide complex, hydrolase, human insulin-degrading enzyme, ubiquitin, exosite
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P14735
Ubiquitin: Cytoplasm  P0CG48
Total number of polymer chains4
Total molecular weight246669.95
Kalas, V.,Ralat, L.A.,Tang, W.-J. (deposition date: 2010-08-15, release date: 2010-09-08, Last modification date: 2017-11-08)
Primary citation
Ralat, L.A.,Kalas, V.,Zheng, Z.,Goldman, R.D.,Sosnick, T.R.,Tang, W.J.
Ubiquitin is a novel substrate for human insulin-degrading enzyme.
J.Mol.Biol., 406:454-466, 2011
PubMed: 21185309 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2010.12.026
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers60.1%8.7%0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report