Crystal structure of Zn-bound human insulin-degrading enzyme in complex with insulin B chain

Summary for 2G54

Related2G47 2G48 2G49 2G56
DescriptorInsulin-degrading enzyme, insulin, ZINC ION, ... (5 entities in total)
Functional Keywordsprotein-peptide complex, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308
Total number of polymer chains4
Total molecular weight236605.22
Shen, Y.,Tang, W.-J. (deposition date: 2006-02-22, release date: 2006-10-24, Last modification date: 2011-07-13)
Primary citation
Shen, Y.,Joachimiak, A.,Rosner, M.R.,Tang, W.J.
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443:870-874, 2006
PubMed: 17051221 (PDB entries with the same primary citation)
DOI: 10.1038/nature05143
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.232150.1%6.3%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution