2G54
Crystal structure of Zn-bound human insulin-degrading enzyme in complex with insulin B chain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Insulin-degrading enzyme | polymer | 990 | 114715.1 | 2 | UniProt (Q5T5N2) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) UniProt (by SIFTS) (P14735) In PDB | Homo sapiens (human) | Insulysin, Insulinase, Insulin protease |
2 | C, D | insulin | polymer | 30 | 3434.0 | 2 | UniProt (P01308) Pfam (PF00049) In PDB | ||
3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | A, B | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 2 | Chemie (DIO) | |||
5 | water | water | 18.0 | 787 | Chemie (HOH) |
Sequence modifications
A, B: 42 - 1019 (UniProt: Q5T5N2)
PDB | External Database | Details |
---|---|---|
Met 30 | - | initiating methionine |
His 31 | - | expression tag |
His 32 | - | expression tag |
His 33 | - | expression tag |
His 34 | - | expression tag |
His 35 | - | expression tag |
His 36 | - | expression tag |
Ala 37 | - | cloning artifact |
Ala 38 | - | cloning artifact |
Gly 39 | - | cloning artifact |
Ile 40 | - | cloning artifact |
Pro 41 | - | cloning artifact |
Gln 111 | Glu 111 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 236298.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 307.0 | |
All* | Total formula weight | 236605.2 |