Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 354 件
7U6E
DownloadVisualize
BU of 7u6e by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ...
著者Kirk, N.S, Lawrence, M.C.
登録日2022-03-03
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
5HYJ
DownloadVisualize
BU of 5hyj by Molmil
1E6 TCR in Complex with HLA-A02 carrying AQWGPDPAAA
分子名称: ALA-GLN-TRP-GLY-PRO-ASP-PRO-ALA-ALA-ALA, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Rizkallah, P.J, Bulek, A.M, Cole, D.K, Sewell, A.K.
登録日2016-02-01
公開日2016-05-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献A "hotspot" for autoimmune T cells in type 1 diabetes.
J.Clin.Invest., 126, 2016
7SL7
DownloadVisualize
BU of 7sl7 by Molmil
Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and site 2 binding deficient mutant insulin (A-L13R)
分子名称: Insulin A chain (L13R), Insulin A chain (V3E), Insulin B chain, ...
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
8SBD
DownloadVisualize
BU of 8sbd by Molmil
Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments
分子名称: Insulin A chain, Insulin B chain
著者Wang, L.W, Hall, C, Uchikawa, E, Chen, D.L, Choi, E, Zhang, X.W, Bai, X.C.
登録日2023-04-03
公開日2023-08-30
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis of insulin fibrillation.
Sci Adv, 9, 2023
6HN5
DownloadVisualize
BU of 6hn5 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ...
著者Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
登録日2018-09-14
公開日2018-11-21
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
5CJO
DownloadVisualize
BU of 5cjo by Molmil
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FAB Heavy chain with engineered elbow, FAB light chain, ...
著者liang, w.g, bailey, L, tang, w.j.
登録日2015-07-14
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.287 Å)
主引用文献Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 2017
7RZE
DownloadVisualize
BU of 7rze by Molmil
Insulin Degrading Enzyme pO/pC
分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7SL3
DownloadVisualize
BU of 7sl3 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- symmetric conformation
分子名称: Insulin A chain, Insulin B chain, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL1
DownloadVisualize
BU of 7sl1 by Molmil
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E)
分子名称: Insulin A chain, Insulin B chain, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7RZF
DownloadVisualize
BU of 7rzf by Molmil
Insulin Degrading Enzyme O/pC
分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7MQO
DownloadVisualize
BU of 7mqo by Molmil
The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, ...
著者Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C.
登録日2021-05-06
公開日2022-03-16
最終更新日2023-03-29
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Nat.Chem.Biol., 18, 2022
8ONK
DownloadVisualize
BU of 8onk by Molmil
Human insulin in complex with the analytical antibody S1 Fab and the analytical antibody HUI-001 Fab
分子名称: Heavy chain of analytical antibody HUI-001 Fab, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ...
著者Johansson, E.
登録日2023-04-03
公開日2024-04-10
実験手法X-RAY DIFFRACTION (3.403 Å)
主引用文献Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils
To Be Published
7STH
DownloadVisualize
BU of 7sth by Molmil
Full-length insulin receptor bound with unsaturated insulin WT (2 insulin bound) symmetric conformation
分子名称: Insulin, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-11-13
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
4OGA
DownloadVisualize
BU of 4oga by Molmil
Insulin in complex with Site 1 of the human insulin receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Lawrence, M.C, Menting, J.G.
登録日2014-01-15
公開日2014-08-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
7YQ3
DownloadVisualize
BU of 7yq3 by Molmil
human insulin receptor bound with A43 DNA aptamer and insulin
分子名称: IR-A43 aptamer, Insulin A chain, Insulin, ...
著者Kim, J, Yunn, N, Ryu, S, Cho, Y.
登録日2022-08-05
公開日2022-11-09
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
7SL2
DownloadVisualize
BU of 7sl2 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- asymmetric conformation
分子名称: Insulin A chain, Insulin B chain, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7V3P
DownloadVisualize
BU of 7v3p by Molmil
Cryo-EM structure of the IGF1R/insulin complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C.
登録日2021-08-11
公開日2022-08-17
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structure of the IGF1R/insulin complex
To Be Published
7SL6
DownloadVisualize
BU of 7sl6 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation
分子名称: Insulin A chain, Insulin B chain, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
6BFC
DownloadVisualize
BU of 6bfc by Molmil
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
分子名称: Insulin, Insulin-degrading enzyme
著者Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J.
登録日2017-10-26
公開日2017-12-27
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6B3Q
DownloadVisualize
BU of 6b3q by Molmil
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
分子名称: Insulin, Insulin-degrading enzyme
著者Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J.
登録日2017-09-22
公開日2017-11-22
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
8EZ0
DownloadVisualize
BU of 8ez0 by Molmil
Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation
分子名称: Insulin, Insulin receptor
著者Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E.
登録日2022-10-29
公開日2022-11-09
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
6B70
DownloadVisualize
BU of 6b70 by Molmil
Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin
分子名称: FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ...
著者Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J.
登録日2017-10-03
公開日2017-12-27
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
7BW8
DownloadVisualize
BU of 7bw8 by Molmil
Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin
分子名称: Insulin fusion, Insulin receptor
著者Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T.
登録日2020-04-14
公開日2021-04-14
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
3W11
DownloadVisualize
BU of 3w11 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Lawrence, M.C, Smith, B.J.
登録日2012-11-06
公開日2013-01-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
7YQ4
DownloadVisualize
BU of 7yq4 by Molmil
human insulin receptor bound with A62 DNA aptamer and insulin - locally refined
分子名称: IR-A62 aptamer, Insulin A chain, Insulin, ...
著者Kim, J, Yunn, N, Ryu, S, Cho, Y.
登録日2022-08-05
公開日2022-11-09
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.95 Å)
主引用文献Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022

222624

件を2024-07-17に公開中

PDB statisticsPDBj update infoContact PDBjnumon