7RZE

Insulin Degrading Enzyme pO/pC

Summary for 7RZE

• Entry DOI: 10.2210/pdb7rze/pdb
• Related: 7RZF 7RZG 7RZH 7RZI
• EMDB information: 24757
• Descriptor: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain (3 entities in total)
• Functional Keywords: m16a zinc metalloprotease, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 239938.65

Authors

Mancl, J.M.,Liang, W.G.,Tang, W.J. (deposition date: 2021-08-27, release date: 2022-08-31, Last modification date: 2025-05-28)

• Primary citation: Mancl, J.M.,Liang, W.G.,Wei, H.,Carragher, B.,Potter, C.S.,Tang, W.J.; Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme; To be published,

Experimental method

ELECTRON MICROSCOPY (3.3 Å)