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7RZE

Insulin Degrading Enzyme pO/pC

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0004175molecular_functionendopeptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005777cellular_componentperoxisome
A0005782cellular_componentperoxisomal matrix
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0008286biological_processinsulin receptor signaling pathway
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010815biological_processbradykinin catabolic process
A0010992biological_processubiquitin recycling
A0016323cellular_componentbasolateral plasma membrane
A0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
A0030163biological_processprotein catabolic process
A0032092biological_processpositive regulation of protein binding
A0042277molecular_functionpeptide binding
A0042447biological_processhormone catabolic process
A0042803molecular_functionprotein homodimerization activity
A0043171biological_processpeptide catabolic process
A0043559molecular_functioninsulin binding
A0045732biological_processpositive regulation of protein catabolic process
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0050435biological_processamyloid-beta metabolic process
A0051603biological_processproteolysis involved in protein catabolic process
A0070062cellular_componentextracellular exosome
A0097242biological_processamyloid-beta clearance
A0150094biological_processamyloid-beta clearance by cellular catabolic process
A1901142biological_processinsulin metabolic process
A1901143biological_processinsulin catabolic process
A1903715biological_processregulation of aerobic respiration
B0001618molecular_functionvirus receptor activity
B0004175molecular_functionendopeptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005777cellular_componentperoxisome
B0005782cellular_componentperoxisomal matrix
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0008286biological_processinsulin receptor signaling pathway
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010815biological_processbradykinin catabolic process
B0010992biological_processubiquitin recycling
B0016323cellular_componentbasolateral plasma membrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0030163biological_processprotein catabolic process
B0032092biological_processpositive regulation of protein binding
B0042277molecular_functionpeptide binding
B0042447biological_processhormone catabolic process
B0042803molecular_functionprotein homodimerization activity
B0043171biological_processpeptide catabolic process
B0043559molecular_functioninsulin binding
B0045732biological_processpositive regulation of protein catabolic process
B0046718biological_processsymbiont entry into host cell
B0046872molecular_functionmetal ion binding
B0050435biological_processamyloid-beta metabolic process
B0051603biological_processproteolysis involved in protein catabolic process
B0070062cellular_componentextracellular exosome
B0097242biological_processamyloid-beta clearance
B0150094biological_processamyloid-beta clearance by cellular catabolic process
B1901142biological_processinsulin metabolic process
B1901143biological_processinsulin catabolic process
B1903715biological_processregulation of aerobic respiration
a0005179molecular_functionhormone activity
a0005576cellular_componentextracellular region
b0005179molecular_functionhormone activity
b0005576cellular_componentextracellular region
Functional Information from PROSITE/UniProt
site_idPS00143
Number of Residues24
DetailsINSULINASE Insulinase family, zinc-binding region signature. GslsdppniaGlSHFLEHMlFlGT
ChainResidueDetails
AGLY95-THR118

site_idPS00262
Number of Residues15
DetailsINSULIN Insulin family signature. CCTSiCSlyqLenyC
ChainResidueDetails
aCYS6-CYS20

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
ChainResidueDetails
AGLU111
BGLU111

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
ChainResidueDetails
AHIS108
AHIS112
AGLU189
BHIS108
BHIS112
BGLU189

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: in the exosite
ChainResidueDetails
AHIS336
BHIS336

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:18986166
ChainResidueDetails
ALEU359
BLEU359

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P35559
ChainResidueDetails
AARG429
AASP895
BARG429
BASP895

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
ChainResidueDetails
ALYS192
ALYS697
BLYS192
BLYS697

226707

PDB entries from 2024-10-30

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