7SL2

Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- asymmetric conformation

Summary for 7SL2

• Entry DOI: 10.2210/pdb7sl2/pdb
• EMDB information: 25188 25189
• Descriptor: Insulin receptor, Insulin B chain, Insulin A chain (3 entities in total)
• Functional Keywords: insulin receptor, site 2 binding deficient mutant insulin, signaling protein, signaling protein-hormone complex, signaling protein/hormone
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 10
• Total formula weight: 335027.78

Authors

Bai, X.C.,Choi, E. (deposition date: 2021-10-22, release date: 2022-03-30, Last modification date: 2022-04-27)

• Primary citation: Li, J.,Park, J.,Mayer, J.P.,Webb, K.J.,Uchikawa, E.,Wu, J.,Liu, S.,Zhang, X.,Stowell, M.H.B.,Choi, E.,Bai, X.C.; Synergistic activation of the insulin receptor via two distinct sites.; Nat.Struct.Mol.Biol., 29:357-368, 2022; PubMed: 35361965; DOI: 10.1038/s41594-022-00750-6

Experimental method

ELECTRON MICROSCOPY (3.6 Å)