8EZ0
Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation
Summary for 8EZ0
Entry DOI | 10.2210/pdb8ez0/pdb |
EMDB information | 28693 28723 28724 28725 |
Descriptor | Insulin receptor, Insulin (2 entities in total) |
Functional Keywords | insulin receptor, insulin, signaling protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 354328.26 |
Authors | |
Primary citation | Li, J.,Wu, J.,Hall, C.,Bai, X.C.,Choi, E. Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11:-, 2022 Cited by PubMed: 36413010DOI: 10.7554/eLife.81286 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.7 Å) |
Structure validation
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