8EZ0
Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Insulin receptor | polymer | 1345 | 153184.4 | 2 | UniProt (P15208) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) Pfam (PF07714) | Mus musculus (house mouse) | IR |
| 2 | C, D, E, F (D, E, F, G) | Insulin | polymer | 110 | 11989.9 | 4 | UniProt (P01308) Pfam (PF00049) | Homo sapiens (human) |
Sequence modifications
A, B: 1 - 1345 (UniProt: P15208)
| PDB | External Database | Details |
|---|---|---|
| Ser 684 | Cys 711 | engineered mutation |
| Ser 685 | Cys 712 | engineered mutation |
| Ser 687 | Cys 714 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 354328.3 | |
| All* | Total formula weight | 354328.3 |
