7SL7
Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and site 2 binding deficient mutant insulin (A-L13R)
Summary for 7SL7
Entry DOI | 10.2210/pdb7sl7/pdb |
EMDB information | 25188 25189 25190 25191 25192 25193 |
Descriptor | Insulin receptor, Insulin B chain, Insulin A chain (L13R), ... (4 entities in total) |
Functional Keywords | insulin receptor, site 1 binding deficient mutant insulin, signaling protein, signaling protein-hormone complex, signaling protein/hormone |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 10 |
Total formula weight | 334999.67 |
Authors | |
Primary citation | Li, J.,Park, J.,Mayer, J.P.,Webb, K.J.,Uchikawa, E.,Wu, J.,Liu, S.,Zhang, X.,Stowell, M.H.B.,Choi, E.,Bai, X.C. Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29:357-368, 2022 Cited by PubMed: 35361965DOI: 10.1038/s41594-022-00750-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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