7SL7
Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and site 2 binding deficient mutant insulin (A-L13R)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Insulin receptor | polymer | 1372 | 155790.5 | 2 | UniProt (P15208) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) Pfam (PF07714) | Mus musculus (house mouse) | IR |
| 2 | C, D, E, F (G, H, I, J) | Insulin B chain | polymer | 30 | 3434.0 | 4 | UniProt (P01308) Pfam (PF00049) | Homo sapiens (human) | |
| 3 | G, H (C, D) | Insulin A chain (L13R) | polymer | 21 | 2427.7 | 2 | UniProt (P01308) | Homo sapiens (human) | |
| 4 | I, J (E, F) | Insulin A chain (V3E) | polymer | 21 | 2413.7 | 2 | UniProt (P01308) | Homo sapiens (human) |
Sequence modifications
C, D: 1 - 21 (UniProt: P01308)
E, F: 1 - 21 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| Arg 13 | Leu 102 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 3 | Val 92 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 334999.7 | |
| All* | Total formula weight | 334999.7 |
