7RZF

Insulin Degrading Enzyme O/pC

Summary for 7RZF

• Entry DOI: 10.2210/pdb7rzf/pdb
• Related: 7RZF 7RZG 7RZH 7RZI
• EMDB information: 24758
• Descriptor: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain (3 entities in total)
• Functional Keywords: m16a zinc metalloprotease, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 239938.65

Authors

Mancl, J.M.,Liang, W.G.,Tang, W.J. (deposition date: 2021-08-27, release date: 2022-08-31, Last modification date: 2026-06-10)

• Primary citation: Mancl, J.M.,Liang, W.G.,Bayhi, N.L.,Wei, H.,Budell, W.,Mendez, J.H.,Sosnick, T.R.,Carragher, B.,Potter, C.S.,Tang, W.J.; Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity; Elife, 2026; DOI: 10.7554/elife.105761.3

Experimental method

ELECTRON MICROSCOPY (3.4 Å)