7RZF

Insulin Degrading Enzyme O/pC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Cysteine-free Insulin-degrading enzyme	polymer	1011	117068.5	2	UniProt (P14735) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) In PDB	Homo sapiens (Human)	Abeta-degrading protease,Insulin protease,Insulinase,Insulysin
2	a	Insulin A chain	polymer	21	2383.7	1	UniProt (P01308) In PDB	Homo sapiens (Human)
3	b	Insulin B chain	polymer	30	3417.9	1	UniProt (P01308) Pfam (PF00049) In PDB	Homo sapiens (Human)

Sequence modifications

A, B: 1 - 1011 (UniProt: P14735)

PDB	External Database	Details
Leu 110	Cys 110	engineered mutation
Ser 171	Cys 171	engineered mutation
Ala 178	Cys 178	engineered mutation
Val 257	Cys 257	engineered mutation
Leu 414	Cys 414	engineered mutation
Asn 573	Cys 573	engineered mutation
Ser 590	Cys 590	engineered mutation
Ser 789	Cys 789	engineered mutation
Ala 812	Cys 812	engineered mutation
Ala 819	Cys 819	engineered mutation
Ser 904	Cys 904	engineered mutation
Ser 966	Cys 966	engineered mutation
Ser 974	Cys 974	engineered mutation

b: 1 - 30 (UniProt: P01308)

PDB	External Database	Details
Leu 29	Lys 53	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	239938.6
All*	Total formula weight	239938.6

*Water molecules are not included.